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Tbio
RACGAP1
Rac GTPase-activating protein 1

Protein Summary
Description
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. This gene encodes a GTPase-activating protein (GAP) that is a compoment of the central ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312377
  • ENSP00000309871
  • ENSG00000161800
  • ENST00000427314
  • ENSP00000404190
  • ENST00000454520
  • ENSP00000404808
  • ENST00000547905
  • ENSP00000449370
  • ENST00000551016
  • ENSP00000449374

Symbol
  • KIAA1478
  • MGCRACGAP
  • CYK4
  • ID-GAP
  • HsCYK-4
  • MgcRacGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.99
molecular function
0.91
cellular component
0.81
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.2   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 498   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.2   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0