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Tbio
RACGAP1
Rac GTPase-activating protein 1

Protein Summary
Description
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. This gene encodes a GTPase-activating protein (GAP) that is a compoment of the central ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312377
  • ENSP00000309871
  • ENSG00000161800
  • ENST00000427314
  • ENSP00000404190
  • ENST00000454520
  • ENSP00000404808
  • ENST00000547905
  • ENSP00000449370
  • ENST00000551016
  • ENSP00000449374

Symbol
  • KIAA1478
  • MGCRACGAP
  • CYK4
  • ID-GAP
  • HsCYK-4
  • MgcRacGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.99
molecular function
0.91
cellular component
0.81
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 498   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (377)
KIF23
Tbio
Novelty:  0.00719651
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SHCBP1
Tbio
Novelty:  0.09160318
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.917
Data Source:  BioPlex,STRINGDB
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.999960564
p_ni:  0.000039434
p_wrong:  1e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.998501468
p_ni:  0.001498454
p_wrong:  7.9e-8
Data Source:  BioPlex
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.989219864
p_ni:  0.006175508
p_wrong:  0.004604628
Data Source:  BioPlex
CD2AP
Tbio
Novelty:  0.00603034
p_int:  0.970634322
p_ni:  0.029365678
Score:  0.352
Data Source:  BioPlex,STRINGDB
TNFRSF8
Tclin
Novelty:  0.00030231
p_int:  0.951803123
p_ni:  0.00021388
p_wrong:  0.047982997
Score:  0.177
Data Source:  BioPlex,STRINGDB
CSTF1
Tbio
Novelty:  0.08711712
p_int:  0.869281706
p_ni:  0.13071828
p_wrong:  1.4e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.866386091
p_ni:  0.133613909
Score:  0.799
Data Source:  BioPlex,STRINGDB
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.761964123
p_ni:  0.238035877
Score:  0.18
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (275)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
50.6
comparative body size at age 10, self-reported
1
1
1
50.6
BMI-adjusted hip circumference
1
1
1
42.3
1
1
0
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
50.6
comparative body size at age 10, self-reported
1
50.6
BMI-adjusted hip circumference
1
42.3
0
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rac GTPase activating protein 1
VGNC:5561
451887
Mouse
MGI:1349423
26934
Rat
RGD:1305912
315298
Dog
Rac GTPase activating protein 1
VGNC:45308
486549
Horse
Rac GTPase activating protein 1
VGNC:22140
100059818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rac GTPase activating protein 1
Mouse
Rat
Dog
Rac GTPase activating protein 1
Horse
Rac GTPase activating protein 1
Publication Statistics
PubMed Score 95.65
PubMed score by year
PubTator Score 60.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title