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Tbio
SHARPIN
Sharpin

Protein Summary
Description
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359551
  • ENSP00000352551
  • ENSG00000179526
  • ENST00000398712
  • ENSP00000381698

Symbol
  • SIPL1
  • SIPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.81
cellular component
0.77
tissue sample
0.65
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.8   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.8   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
1
3
82.5
blood metabolite measurement
1
1
1
81.2
mean corpuscular hemoglobin concentration
1
1
1
80.2
eosinophil percentage of leukocytes
2
1
2
60
2
1
0
1.1
47.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
82.5
blood metabolite measurement
1
81.2
mean corpuscular hemoglobin concentration
1
80.2
eosinophil percentage of leukocytes
2
60
0
1.1
47.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913331
106025
Rat
RGD:631353
81859
Dog
SHANK associated RH domain interactor
VGNC:49813
475122
Horse
SHANK associated RH domain interactor
100065232
Cow
SHANK associated RH domain interactor
VGNC:34587
512499
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SHANK associated RH domain interactor
Horse
SHANK associated RH domain interactor
Cow
SHANK associated RH domain interactor
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Regulation of TNFR1 signaling
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
RBCK1
Tbio
Novelty: 0.02760333
p_int: 0.999999994
p_ni: 6e-9
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
RNF31
Tbio
Family: Enzyme
Novelty: 0.01394304
p_int: 0.9999998
p_ni: 2e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCAF12
Tbio
Novelty: 0.15472702
p_int: 0.999995291
p_ni: 0.000004707
p_wrong: 2e-9
Data Source: BioPlex
LIPF
Tclin
Family: Enzyme
Novelty: 0.03073254
p_int: 0.999979492
p_ni: 1.39e-7
p_wrong: 0.000020369
Score: 0.823
Data Source: BioPlex,STRINGDB
CSRNP1
Tbio
Novelty: 0.10538864
p_int: 0.999853999
p_ni: 0.000142709
p_wrong: 0.000003292
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999831314
p_ni: 0.000148398
p_wrong: 0.000020288
Score: 0.303
Data Source: BioPlex,STRINGDB
ADIPOQ
Tbio
Novelty: 0.00011196
p_int: 0.99981851
p_ni: 0.000048553
p_wrong: 0.000132937
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.999671889
p_ni: 0.000300425
p_wrong: 0.000027686
Score: 0.67
Data Source: BioPlex,STRINGDB
HIPK1
Tchem
Family: Kinase
Novelty: 0.11377215
p_int: 0.999659089
p_ni: 0.000019769
p_wrong: 0.000321142
Data Source: BioPlex
SAMD11
Tdark
Novelty: 0.32977476
p_int: 0.999551449
p_ni: 0.000339642
p_wrong: 0.000108908
Data Source: BioPlex
Publication Statistics
PubMed Score  65.80

PubMed score by year
PubTator Score  30.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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