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Tbio
RNF38
E3 ubiquitin-protein ligase RNF38

Protein Summary
Description
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259605
  • ENSP00000259605
  • ENSG00000137075
  • ENST00000350199
  • ENSP00000343947
  • ENST00000353739
  • ENSP00000335239
  • ENST00000357058
  • ENSP00000349566
  • ENST00000377877
  • ENSP00000367109
  • ENST00000377885
  • ENSP00000367117
  • ENST00000611646
  • ENSP00000483536
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
kinase perturbation
0.76
microRNA
0.74
transcription factor perturbation
0.74
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
1.8
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.8
1
1.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 38
VGNC:4852
473232
Macaque
ring finger protein 38
693346
Mouse
MGI:1920719
73469
Rat
RGD:621856
171501
Dog
ring finger protein 38
VGNC:45668
474766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 38
Macaque
ring finger protein 38
Mouse
Rat
Dog
ring finger protein 38
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0F5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.982
Data Source:  STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.907
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.863
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.807
Data Source:  STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
Score:  0.787
Data Source:  STRINGDB
PIN4
Tbio
Family:  Enzyme
Novelty:  0.01193983
Score:  0.685
Data Source:  STRINGDB
BNIP1
Tbio
Novelty:  0.04601895
Score:  0.621
Data Source:  STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
Score:  0.62
Data Source:  STRINGDB
PTPN9
Tchem
Family:  Enzyme
Novelty:  0.01574113
Score:  0.617
Data Source:  STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
Score:  0.571
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.45

PubMed score by year
PubTator Score  2.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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