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Tdark
SAP130
Histone deacetylase complex subunit SAP130

Protein Summary
Description
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259235
  • ENSP00000259235
  • ENSG00000136715
  • ENST00000357702
  • ENSP00000350333
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.82
kinase perturbation
0.76
transcription factor
0.73
biological process
0.69


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 130
VGNC:2806
470529
Macaque
Sin3A associated protein 130
715151
Mouse
MGI:1919782
269003
Dog
Sin3A associated protein 130
VGNC:45858
476102
Horse
Sin3A associated protein 130
VGNC:22685
100067466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sin3A associated protein 130
Macaque
Sin3A associated protein 130
Mouse
Dog
Sin3A associated protein 130
Horse
Sin3A associated protein 130
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
HATs acetylate histones
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (132)
1 – 10 of 132
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.999999987
p_ni: 1.1e-8
p_wrong: 1e-9
Score: 0.838
Data Source: BioPlex,STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.999999907
p_ni: 9.3e-8
Score: 0.943
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.99999684
p_ni: 0.00000316
Score: 0.954
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.99999603
p_ni: 0.000003969
Score: 0.832
Data Source: BioPlex,STRINGDB
ZNF704
Tdark
Novelty: 0.34442716
p_int: 0.99944117
p_ni: 0.00055883
Score: 0.534
Data Source: BioPlex,STRINGDB
MXD3
Tbio
Family: TF
Novelty: 0.07436584
p_int: 0.999292828
p_ni: 0.000707157
p_wrong: 1.4e-8
Score: 0.655
Data Source: BioPlex,STRINGDB
MXD1
Tbio
Family: TF
Novelty: 0.0353468
p_int: 0.999055064
p_ni: 0.000944936
Score: 0.285
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.995603037
p_ni: 0.004396963
Data Source: BioPlex
PHF23
Tbio
Family: Epigenetic
Novelty: 0.17699844
p_int: 0.990352281
p_ni: 0.009647691
p_wrong: 2.8e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.989045182
p_ni: 0.010954815
p_wrong: 3e-9
Score: 0.172
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.70

PubMed score by year
PubTator Score  4.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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