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Tbio
TOLLIP
Toll-interacting protein

Protein Summary
Description
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317204
  • ENSP00000314733
  • ENSG00000078902
  • ENST00000527886
  • ENSP00000434035

Symbol
  • IL-1RAcPIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.9
histone modification site profile
0.73
molecular function
0.67
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.76   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 527   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.76   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 527   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
1.6
82.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
82.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
toll interacting protein
702587
Mouse
MGI:1891808
54473
Rat
RGD:1304676
361677
Dog
toll interacting protein
VGNC:52056
483657
Horse
toll interacting protein
VGNC:24407
100051383
Species
Name
OMA
EggNOG
Inparanoid
Macaque
toll interacting protein
Mouse
Rat
Dog
toll interacting protein
Horse
toll interacting protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H0E2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (222)
1 – 10 of 222
TOM1L1
Tbio
Novelty: 0.09426366
p_int: 0.999999981
p_ni: 1e-9
p_wrong: 1.8e-8
Score: 0.689
Data Source: BioPlex,STRINGDB
CSTF1
Tbio
Novelty: 0.08711712
p_int: 0.999981598
p_ni: 0.000018402
Score: 0.183
Data Source: BioPlex,STRINGDB
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
p_int: 0.998237385
p_ni: 0.001762576
p_wrong: 3.9e-8
Data Source: BioPlex
TOM1L2
Tdark
Novelty: 0.1647296
p_int: 0.988422665
p_ni: 0.011577335
Score: 0.708
Data Source: BioPlex,STRINGDB
TOM1
Tbio
Novelty: 0.00725956
p_int: 0.931620828
p_ni: 0.068379172
Score: 0.928
Data Source: BioPlex,STRINGDB
CDK5RAP1
Tbio
Novelty: 0.0347805
p_int: 0.787144312
p_ni: 0.212855688
Data Source: BioPlex
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.992
Data Source: Reactome,STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.99
Data Source: STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.01496024
Score: 0.987
Data Source: STRINGDB
IL1R1
Tclin
Novelty: 0.0014281
Score: 0.979
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  114.76

PubMed score by year
PubTator Score  59.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer