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Tbio
XRN2
5'-3' exoribonuclease 2

Protein Summary
Description
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.96
molecular function
0.94
histone modification site profile
0.91
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.59   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.59   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
77.8
red blood cell distribution width
2
2
2
69.2
red blood cell density measurement
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
77.8
red blood cell distribution width
2
69.2
red blood cell density measurement
1
43.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-3' exoribonuclease 2
VGNC:6307
458131
Macaque
5'-3' exoribonuclease 2
700934
Mouse
MGI:894687
24128
Dog
5'-3' exoribonuclease 2
VGNC:48472
477133
Horse
5'-3' exoribonuclease 2
VGNC:25086
100050094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-3' exoribonuclease 2
Macaque
5'-3' exoribonuclease 2
Mouse
Dog
5'-3' exoribonuclease 2
Horse
5'-3' exoribonuclease 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H0D6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Metabolism of proteins
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (251)
1 – 10 of 251
CDKN2AIP
Tbio
Novelty: 0.15331029
p_int: 0.999932995
p_ni: 0.000067005
Score: 0.966
Data Source: BioPlex,STRINGDB
DXO
Tbio
Family: Enzyme
Novelty: 0.08260087
Score: 0.995
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.983
Data Source: STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
Score: 0.962
Data Source: STRINGDB
RCL1
Tbio
Family: Enzyme
Novelty: 0.02116964
Score: 0.95
Data Source: STRINGDB
FBL
Tbio
Family: Enzyme
Novelty: 0.00080634
Score: 0.948
Data Source: STRINGDB
DDX49
Tbio
Family: Enzyme
Novelty: 0.14100169
Score: 0.946
Data Source: STRINGDB
DHX37
Tdark
Family: Enzyme
Novelty: 0.02474351
Score: 0.935
Data Source: STRINGDB
RRP7A
Tbio
Novelty: 0.11315285
Score: 0.934
Data Source: STRINGDB
FCF1
Tdark
Novelty: 0.04202976
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.59

PubMed score by year
PubTator Score  38.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer