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Tbio
ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

Protein Summary
Description
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254654
  • ENSP00000254654
  • ENSG00000132323

Symbol
  • PPM1O
  • ILKAP2
  • ILKAP3
  • PP2C-DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.9
interacting protein
0.89
ligand (protein) perturbation
0.83
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
19.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
19.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ILK associated serine/threonine phosphatase
VGNC:1973
746056
Macaque
ILK associated serine/threonine phosphatase
706334
Mouse
MGI:1914694
67444
Rat
RGD:620128
64538
Dog
ILK associated serine/threonine phosphatase
VGNC:42002
486179
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ILK associated serine/threonine phosphatase
Macaque
ILK associated serine/threonine phosphatase
Mouse
Rat
Dog
ILK associated serine/threonine phosphatase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H0C8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (37)
1 – 10 of 37
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.778204212
p_ni: 0.221795788
Score: 0.163
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.750199731
p_ni: 0.249800269
Score: 0.167
Data Source: BioPlex,STRINGDB
ILK
Tchem
Family: Kinase
Novelty: 0.00147344
Score: 0.984
Data Source: STRINGDB
CHEK2
Tchem
Family: Kinase
Novelty: 0.00068355
Score: 0.928
Data Source: STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
Score: 0.915
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.894
Data Source: STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
Score: 0.862
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.853
Data Source: STRINGDB
FAM131A
Tdark
Novelty: 1.91916255
Score: 0.765
Data Source: STRINGDB
MAEL
Tbio
Novelty: 0.01925239
Score: 0.668
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.63

PubMed score by year
PubTator Score  7.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer