Tbio BTBD1 BTB/POZ domain-containing protein 1

Protein Summary

Description

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H0C5
• A6NMI8
• Q9BX71
• Q9NWN4

Gene Name

• BTBD1

Ensembl ID

• ENST00000261721
• ENSP00000261721
• ENSG00000064726
• ENST00000379403
• ENSP00000368713

Symbol

• C15orf1
• NS5ATP8
• C15orf1
• NS5ATP8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
disease perturbation	0.87
transcription factor perturbation	0.84
kinase perturbation	0.81
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / ... / Dna Topoisomerase / Btb/poz Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Isomerase / Dna Topoisomerase / Btb/poz Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0