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Tbio
SLC25A31
ADP/ATP translocase 4

Protein Summary
Description
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281154
  • ENSP00000281154
  • ENSG00000151475

Symbol
  • AAC4
  • ANT4
  • SFEC
  • AAC4
  • ANT4
  • ANT 4
  • SFEC35kDa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
cellular component
0.64
tissue sample
0.63
protein domain
0.58
PubMedID
0.51


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.84   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.84   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
35
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 31
VGNC:7725
742937
Mouse
MGI:1920583
73333
Rat
RGD:1596195
689108
Dog
solute carrier family 25 member 31
VGNC:46305
483832
Horse
solute carrier family 25 member 31
VGNC:23104
100071908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 31
Mouse
Rat
Dog
solute carrier family 25 member 31
Horse
solute carrier family 25 member 31
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H0C2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human T-cell leukemia virus 1 infection
KEGG
Huntington disease
KEGG
Necroptosis
KEGG
Calcium signaling pathway
KEGG
Parkinson disease
Name
Explore in Pharos
Explore in Source
Human T-cell leukemia virus 1 infection
Huntington disease
Necroptosis
Calcium signaling pathway
Parkinson disease
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (40)
1 – 10 of 40
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.993757004
p_ni:  8.6e-8
p_wrong:  0.00624291
Data Source:  BioPlex
PSMB5
Tclin
Family:  Enzyme
Novelty:  0.01864909
p_int:  0.977078047
p_ni:  6.7e-8
p_wrong:  0.022921885
Data Source:  BioPlex
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.954303834
p_ni:  9e-9
p_wrong:  0.045696157
Data Source:  BioPlex
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.899
Data Source:  STRINGDB
PPIF
Tchem
Family:  Enzyme
Novelty:  0.00147732
Score:  0.898
Data Source:  STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
Score:  0.891
Data Source:  STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.89
Data Source:  STRINGDB
TSPO
Tchem
Novelty:  0.00082324
Score:  0.858
Data Source:  STRINGDB
TSPO
Tchem
Novelty:  0.00082324
Score:  0.858
Data Source:  STRINGDB
PPID
Tchem
Family:  Enzyme
Novelty:  0.01068886
Score:  0.813
Data Source:  STRINGDB
Publication Statistics
PubMed Score  47.84

PubMed score by year
PubTator Score  19.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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