Tbio KLC2 Kinesin light chain 2

Protein Summary

Description

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9H0B6
• A8MXL7
• B2RDY4
• Q9H9C8
• Q9HA20
• KLC 2

Gene Name

• KLC2

Ensembl ID

• ENST00000316924
• ENSP00000314837
• ENSG00000174996
• ENST00000394066
• ENSP00000377630
• ENST00000394067
• ENSP00000377631
• ENST00000417856
• ENSP00000399403
• ENST00000421552
• ENSP00000408484

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
protein domain	0.92
transcription factor binding site profile	0.83
kinase perturbation	0.76
small molecule perturbation	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.81   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.81   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0