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Tbio
KLC2
Kinesin light chain 2

Protein Summary
Description
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316924
  • ENSP00000314837
  • ENSG00000174996
  • ENST00000394066
  • ENSP00000377630
  • ENST00000394067
  • ENSP00000377631
  • ENST00000417856
  • ENSP00000399403
  • ENST00000421552
  • ENSP00000408484
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.83
kinase perturbation
0.76
small molecule perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (206)
1 – 10 of 206
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999999811
p_ni:  1.89e-7
Score:  0.597
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.99999939
p_ni:  6.1e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999995342
p_ni:  0.000004658
Score:  0.159
Data Source:  BioPlex,STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
p_int:  0.999994607
p_ni:  0.000005393
Score:  0.234
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.99999333
p_ni:  0.00000667
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.999950624
p_ni:  0.000049373
p_wrong:  4e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.99990752
p_ni:  0.00009248
Score:  0.313
Data Source:  BioPlex,STRINGDB
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.99974639
p_ni:  0.00025361
Score:  0.392
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.999530412
p_ni:  0.000469588
Data Source:  BioPlex
AZIN1
Tbio
Family:  Enzyme
Novelty:  0.03017595
p_int:  0.999323795
p_ni:  0.000676205
Score:  0.739
Data Source:  BioPlex,STRINGDB
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
3
78.7
BMI-adjusted hip circumference
2
2
3
68.1
insomnia measurement
1
2
0
1
67.5
BMI-adjusted waist circumference
1
2
2
67.5
self reported educational attainment
3
2
3
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
78.7
BMI-adjusted hip circumference
3
68.1
insomnia measurement
0
1
67.5
BMI-adjusted waist circumference
2
67.5
self reported educational attainment
3
67.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 2
VGNC:1083
466670
Macaque
kinesin light chain 2
714643
Mouse
MGI:107953
16594
Rat
RGD:1307377
309159
Dog
kinesin light chain 2
VGNC:42427
483715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin light chain 2
Macaque
kinesin light chain 2
Mouse
Rat
Dog
kinesin light chain 2
Publication Statistics
PubMed Score 17.01
PubMed score by year
PubTator Score 8.26
PubTator score by year