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Tbio
IQCG
Dynein regulatory complex protein 9

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265239
  • ENSP00000265239
  • ENSG00000114473
  • ENST00000455191
  • ENSP00000407736

Symbol
  • DRC9
  • DRC9
  • CFAP122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
gene perturbation
0.64
transcription factor binding site profile
0.63
kinase perturbation
0.6
small molecule perturbation
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing G
VGNC:1855
460975
Macaque
IQ motif containing G
714807
Mouse
MGI:1916957
69707
Rat
RGD:1311606
363796
Dog
IQ motif containing G
VGNC:42079
488020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing G
Macaque
IQ motif containing G
Mouse
Rat
Dog
IQ motif containing G
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (62)
1 – 10 of 62
CALM2
Tclin
Novelty: 0.01876254
Score: 0.833
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.833
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.831
Data Source: STRINGDB
IQCD
Tbio
Novelty: 0.21789956
Score: 0.821
Data Source: STRINGDB
IQCA1
Tdark
Novelty: 0.33986781
Score: 0.819
Data Source: STRINGDB
EFCAB2
Tdark
Novelty: 0.26420728
Score: 0.745
Data Source: STRINGDB
MEIG1
Tdark
Novelty: 1.04256307
Score: 0.712
Data Source: STRINGDB
EXOSC2
Tbio
Novelty: 0.08163283
Score: 0.668
Data Source: STRINGDB
CAMK4
Tbio
Family: Kinase
Novelty: 0.00412444
Score: 0.636
Data Source: STRINGDB
USP32
Tbio
Family: Enzyme
Novelty: 0.08043957
Score: 0.607
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.07

PubMed score by year
PubTator Score  2.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer