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Tchem
NUAK2
NUAK family SNF1-like kinase 2

Protein Summary
Description
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367157
  • ENSP00000356125
  • ENSG00000163545

Symbol
  • OMPHK2
  • SNARK
  • SNARK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.95
small molecule
0.95
drug perturbation
0.87
transcription factor binding site profile
0.81


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.21   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.21   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NUAK family kinase 2
VGNC:11561
457667
Macaque
NUAK family kinase 2
700529
Mouse
MGI:1921387
74137
Rat
RGD:1359167
289419
Dog
NUAK family kinase 2
VGNC:53124
488570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NUAK family kinase 2
Macaque
NUAK family kinase 2
Mouse
Rat
Dog
NUAK family kinase 2
Protein-Protein Interactions (18)
1 – 10 of 18
HSP90AB3P
Tdark
p_int: 0.999989573
p_ni: 0.000010424
p_wrong: 3e-9
Data Source: BioPlex
LZTR1
Tbio
Novelty: 0.02363333
p_int: 0.999914977
p_ni: 0.000084973
p_wrong: 5e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
PPP1R12A
Tbio
Family: Enzyme
Novelty: 0.0028297
p_int: 0.999711861
p_ni: 0.000288139
Score: 0.746
Data Source: BioPlex,STRINGDB
MARK3
Tchem
Family: Kinase
Novelty: 0.01304552
p_int: 0.999118004
p_ni: 0.000881995
Score: 0.304
Data Source: BioPlex,STRINGDB
UBXN7
Tbio
Novelty: 0.07437638
p_int: 0.998702967
p_ni: 0.001296983
p_wrong: 5e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
FLNC
Tbio
Novelty: 0.00463205
p_int: 0.99673498
p_ni: 0.00326502
Score: 0.218
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.994208005
p_ni: 0.005791995
Score: 0.476
Data Source: BioPlex,STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.981779907
p_ni: 0.018220093
Data Source: BioPlex
MARK2
Tchem
Family: Kinase
Novelty: 0.00437762
p_int: 0.97877846
p_ni: 0.021221525
p_wrong: 1.5e-8
Score: 0.274
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.969425078
p_ni: 0.030574922
Score: 0.463
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.21

PubMed score by year
PubTator Score  40.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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