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Tbio
LSG1
Large subunit GTPase 1 homolog

Protein Summary
Description
GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265245
  • ENSP00000265245
  • ENSG00000041802
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.96
virus perturbation
0.92
molecular function
0.9
interacting protein
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.48   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999991358
p_ni:  0.000008642
Score:  0.212
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999986706
p_ni:  0.000013294
Score:  0.174
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.99911743
p_ni:  0.000882568
p_wrong:  1e-9
Data Source:  BioPlex
PLPPR1
Tdark
Family:  Enzyme
Novelty:  0.38109551
p_int:  0.932824146
p_ni:  0.067175854
Score:  0.209
Data Source:  BioPlex,STRINGDB
TTC29
Tdark
Novelty:  0.1887357
p_int:  0.909966061
p_ni:  0.090033939
Score:  0.232
Data Source:  BioPlex,STRINGDB
NMD3
Tbio
Novelty:  0.03505289
Score:  0.996
Data Source:  STRINGDB
WDR12
Tbio
Novelty:  0.03409059
Score:  0.95
Data Source:  STRINGDB
GTPBP4
Tchem
Novelty:  0.00062563
Score:  0.948
Data Source:  STRINGDB
TSR1
Tbio
Novelty:  0.01639069
Score:  0.939
Data Source:  STRINGDB
RPF2
Tbio
Novelty:  0.04148504
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
60.2
reticulocyte measurement
1
1
1
52
diastolic blood pressure
1
1
1
24.2
eosinophil percentage of leukocytes
1
1
1
17.4
electrocardiography
1
1
64
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
60.2
reticulocyte measurement
1
52
diastolic blood pressure
1
24.2
eosinophil percentage of leukocytes
1
17.4
electrocardiography
64
15.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
large 60S subunit nuclear export GTPase 1
VGNC:1865
460944
Macaque
large 60S subunit nuclear export GTPase 1
708114
Mouse
MGI:107236
224092
Rat
RGD:1309089
288029
Dog
large 60S subunit nuclear export GTPase 1
VGNC:42837
478606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
large 60S subunit nuclear export GTPase 1
Macaque
large 60S subunit nuclear export GTPase 1
Mouse
Rat
Dog
large 60S subunit nuclear export GTPase 1
Publication Statistics
PubMed Score 21.48
PubMed score by year
PubTator Score 8.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title