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Tbio
RAB33B
Ras-related protein Rab-33B

Protein Summary
Description
Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation. This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305626
  • ENSP00000306496
  • ENSG00000172007

Symbol
  • SMC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
molecular function
0.91
transcription factor binding site profile
0.89
protein complex
0.84
histone modification site profile
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB33B, member RAS oncogene family
VGNC:7580
461496
Macaque
RAB33B, member RAS oncogene family
697603
Mouse
MGI:1330805
19338
Rat
RGD:1308353
365793
Dog
RAB33B, member RAS oncogene family
VGNC:45276
100685754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB33B, member RAS oncogene family
Macaque
RAB33B, member RAS oncogene family
Mouse
Rat
Dog
RAB33B, member RAS oncogene family
Pathways (10)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (156)
1 – 10 of 156
SWSAP1
Tbio
Family: Enzyme
Novelty: 0.39530563
p_int: 0.99999997
p_ni: 8e-9
p_wrong: 2.3e-8
Data Source: BioPlex
ATG5
Tbio
Novelty: 0.00081472
p_int: 0.999999833
p_ni: 1.67e-7
p_wrong: 1e-9
Score: 0.512
Data Source: BioPlex,STRINGDB
ATG12
Tbio
Novelty: 0.00304298
p_int: 0.999999235
p_ni: 7.65e-7
p_wrong: 1e-9
Score: 0.507
Data Source: BioPlex,STRINGDB
RAB33A
Tbio
Family: Enzyme
Novelty: 0.11617001
p_int: 0.999998085
p_ni: 1e-9
p_wrong: 0.000001914
Score: 0.905
Data Source: BioPlex,STRINGDB
ATG16L1
Tbio
Novelty: 0.0031765
p_int: 0.999992914
p_ni: 0.000007086
Score: 0.976
Data Source: BioPlex,STRINGDB
RAB43
Tbio
Family: Enzyme
Novelty: 0.07527576
p_int: 0.995196597
p_ni: 0.004803323
p_wrong: 8e-8
Score: 0.912
Data Source: BioPlex,STRINGDB
EPN1
Tbio
Novelty: 0.01788784
p_int: 0.991793495
p_ni: 0.008201103
p_wrong: 0.000005403
Data Source: BioPlex
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
p_int: 0.987041532
p_ni: 0.012955568
p_wrong: 0.0000029
Score: 0.928
Data Source: BioPlex,STRINGDB
UFSP2
Tbio
Family: Enzyme
Novelty: 0.12630722
p_int: 0.972959416
p_ni: 0.027040584
Data Source: BioPlex
RAB39B
Tbio
Family: Enzyme
Novelty: 0.02362498
p_int: 0.966728245
p_ni: 0.033270954
p_wrong: 8.01e-7
Score: 0.938
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.37

PubMed score by year
PubTator Score  9.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer