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Tbio
MIS12
Protein MIS12 homolog

Protein Summary
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381165
  • ENSP00000370557
  • ENSG00000167842
  • ENST00000573759
  • ENSP00000461252
  • ENST00000611091
  • ENSP00000484532

Symbol
  • MTW1
  • hMis12
  • KNTC2AP
  • 2510025F08Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.74
tissue sample
0.66
microRNA
0.65
transcription factor binding site profile
0.61


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MIS12, kinetochore complex component
VGNC:14184
468170
Mouse
MGI:1914389
67139
Rat
RGD:1564837
501706
Dog
protein MIS12 homolog
102154136
Horse
MIS12, kinetochore complex component
VGNC:20199
100060987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MIS12, kinetochore complex component
Mouse
Rat
Dog
protein MIS12 homolog
Horse
MIS12, kinetochore complex component
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H081-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Protein-Protein Interactions (146)
1 – 10 of 146
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.999999698
p_ni: 3.02e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty: 0.01396984
p_int: 0.999999644
p_ni: 3.54e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty: 0.26354244
p_int: 0.99999885
p_ni: 0.00000115
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 0.99999881
p_ni: 0.000001187
p_wrong: 3e-9
Score: 0.943
Data Source: BioPlex,Reactome,STRINGDB
SPC24
Tbio
Novelty: 0.03166479
p_int: 0.999998465
p_ni: 0.000001535
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZWINT
Tbio
Novelty: 0.02153276
p_int: 0.999881442
p_ni: 0.000118557
Score: 0.997
Data Source: BioPlex,STRINGDB
CENPC
Tbio
Novelty: 0.00638662
p_int: 0.998889356
p_ni: 0.001018154
p_wrong: 0.00009249
Score: 0.999
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.99883146
p_ni: 0.000614221
p_wrong: 0.000554319
Score: 0.966
Data Source: BioPlex,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.998338857
p_ni: 0.001553424
p_wrong: 0.000107719
Data Source: BioPlex
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
p_int: 0.978090616
p_ni: 0.021580952
p_wrong: 0.000328432
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.85

PubMed score by year
PubTator Score  23.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer