Tbio PAIP1 Polyadenylate-binding protein-interacting protein 1

Protein Summary

Description

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H074
• A6NKV8
• O60455
• Q96B61
• Q9BS63
• PABP-interacting protein 1

Gene Name

• PAIP1

Ensembl ID

• ENST00000306846
• ENSP00000302768
• ENSG00000172239
• ENST00000338972
• ENSP00000339622
• ENST00000436644
• ENSP00000387729

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
gene perturbation	0.81
disease perturbation	0.79
virus perturbation	0.76
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Polyadenylate-binding Protein-interacting Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Polyadenylate-binding Protein-interacting Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.18   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0