You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

Protein Classes
Protein Summary
Description
Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322428
  • ENSP00000318604
  • ENSG00000179632
  • ENST00000532522
  • ENSP00000436720
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
histone modification site profile
0.84
molecular function
0.73
cell type or tissue
0.72
tissue sample
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.27   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.27   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
80.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
80.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAF1 homolog, negative regulator of RNA polymerase III
VGNC:6672
464456
Macaque
MAF1 homolog, negative regulator of RNA polymerase III
700385
Mouse
MGI:1916127
68877
Rat
RGD:1359315
315093
Horse
MAF1 homolog, negative regulator of RNA polymerase III
VGNC:19890
100065171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAF1 homolog, negative regulator of RNA polymerase III
Macaque
MAF1 homolog, negative regulator of RNA polymerase III
Mouse
Rat
Horse
MAF1 homolog, negative regulator of RNA polymerase III
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H063-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN gene transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN gene transcription
Signal Transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
p_int: 0.999471167
p_ni: 0.000353867
p_wrong: 0.000174966
Score: 0.529
Data Source: BioPlex,STRINGDB
VCPIP1
Tbio
Novelty: 0.09915033
p_int: 0.996548844
p_ni: 0.003451155
Score: 0.196
Data Source: BioPlex,STRINGDB
TSR3
Tdark
Novelty: 0.09337944
p_int: 0.995245643
p_ni: 0.004754356
p_wrong: 1e-9
Score: 0.226
Data Source: BioPlex,STRINGDB
ARMCX3
Tdark
Novelty: 0.25544824
p_int: 0.939892046
p_ni: 0.060107954
Score: 0.189
Data Source: BioPlex,STRINGDB
RAD54B
Tbio
Novelty: 0.02431597
p_int: 0.910624016
p_ni: 0.000004635
p_wrong: 0.089371348
Score: 0.335
Data Source: BioPlex,STRINGDB
RAD50
Tbio
Novelty: 0.02161298
p_int: 0.866870475
p_ni: 0.133129525
Score: 0.204
Data Source: BioPlex,STRINGDB
CSNK1D
Tchem
Family: Kinase
Novelty: 0.00896935
p_int: 0.850423533
p_ni: 0.149576466
Score: 0.181
Data Source: BioPlex,STRINGDB
POLR3A
Tbio
Family: Enzyme
Novelty: 0.01508849
p_int: 0.826679311
p_ni: 0.173320689
Score: 0.946
Data Source: BioPlex,STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.979
Data Source: Reactome,STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
Score: 0.941
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  100.27

PubMed score by year
PubTator Score  47.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: