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Tbio
TMEM126A
Transmembrane protein 126A

Protein Summary
Description
The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304511
  • ENSP00000306887
  • ENSG00000171202
  • ENST00000528105
  • ENSP00000436590
  • ENST00000532180
  • ENSP00000434357

Symbol
  • OPA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.83
virus perturbation
0.83
histone modification site profile
0.82
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
54.4
mathematical ability
1
1
1
44.2
age at first sexual intercourse measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
54.4
mathematical ability
1
44.2
age at first sexual intercourse measurement
1
8.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 126A
VGNC:982
451462
Mouse
MGI:1913521
66271
Rat
RGD:1305677
293113
Dog
transmembrane protein 126A
VGNC:47459
608427
Horse
transmembrane protein 126A
VGNC:24188
100061387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 126A
Mouse
Rat
Dog
transmembrane protein 126A
Horse
transmembrane protein 126A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional repression
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional repression
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (117)
1 – 10 of 117
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.999999249
p_ni:  7.51e-7
Data Source:  BioPlex
MIGA1
Tbio
Novelty:  0.08346483
p_int:  0.999991011
p_ni:  0.000008987
p_wrong:  2e-9
Data Source:  BioPlex
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.99998951
p_ni:  0.00001049
Data Source:  BioPlex
LAMB1
Tbio
Novelty:  0.0104285
p_int:  0.999725664
p_ni:  0.000274336
Data Source:  BioPlex
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.997134725
p_ni:  0.002865269
p_wrong:  6e-9
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.99541633
p_ni:  0.004583508
p_wrong:  1.62e-7
Data Source:  BioPlex
DIAPH3
Tbio
Novelty:  0.01165283
p_int:  0.979898971
p_ni:  0.02010045
p_wrong:  5.79e-7
Score:  0.682
Data Source:  BioPlex,STRINGDB
TUBGCP2
Tbio
Novelty:  0.01856674
p_int:  0.938878684
p_ni:  0.061121316
Data Source:  BioPlex
IPO7
Tbio
Novelty:  0.01319011
p_int:  0.903657445
p_ni:  0.096342555
Data Source:  BioPlex
CRELD2
Tbio
Novelty:  0.09438775
p_int:  0.822785551
p_ni:  0.177203079
p_wrong:  0.000011371
Data Source:  BioPlex
Publication Statistics
PubMed Score  10.81

PubMed score by year
PubTator Score  8.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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