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Tbio
SLC22A4
Solute carrier family 22 member 4

Protein Summary
Description
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200652
  • ENSP00000200652
  • ENSG00000197208

Symbol
  • ETT
  • OCTN1
  • UT2H
  • OCTN1
  • DFNB60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
drug
0.92
histone modification site profile
0.87
gene perturbation
0.83
disease
0.81


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.89   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.89   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
12
13
98.3
mean platelet volume
3
3
3
97.5
fibrinogen measurement
3
4
3
6.8
96.3
myeloid white cell count
2
2
2
94.3
2
2
0
1.2
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
13
98.3
mean platelet volume
3
97.5
fibrinogen measurement
3
6.8
96.3
myeloid white cell count
2
94.3
0
1.2
93.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 4
VGNC:8639
743741
Macaque
solute carrier family 22 member 4
710179
Mouse
MGI:1353479
30805
Dog
solute carrier family 22 member 4
VGNC:51760
474673
Horse
solute carrier family 22 member 4
VGNC:23077
100063287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 4
Macaque
solute carrier family 22 member 4
Mouse
Dog
solute carrier family 22 member 4
Horse
solute carrier family 22 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H015-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Organic cation transport (R-HSA-549127)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic cation transport
Reactome
Organic cation/anion/zwitterion transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic cation transport
Organic cation/anion/zwitterion transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
SLC47A2
Tchem
Family:  Transporter
Novelty:  0.01171254
Score:  0.726
Data Source:  STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
Score:  0.722
Data Source:  STRINGDB
PIK3AP1
Tbio
Family:  Enzyme
Novelty:  0.11565645
Score:  0.71
Data Source:  STRINGDB
DLG5
Tbio
Novelty:  0.01630244
Score:  0.68
Data Source:  STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.658
Data Source:  STRINGDB
SLC15A2
Tchem
Family:  Transporter
Novelty:  0.00573108
Score:  0.656
Data Source:  STRINGDB
NOD2
Tclin
Novelty:  0.00059089
Score:  0.639
Data Source:  STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
Score:  0.615
Data Source:  STRINGDB
SLCO1A2
Tchem
Family:  Transporter
Novelty:  0.00248357
Score:  0.605
Data Source:  STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
Score:  0.6
Data Source:  STRINGDB
Publication Statistics
PubMed Score  234.89

PubMed score by year
PubTator Score  138.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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