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Tbio
LHPP
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Protein Classes
Protein Summary
Description
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368839
  • ENSP00000357832
  • ENSG00000107902
  • ENST00000368842
  • ENSP00000357835

Symbol
  • HDHD2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.83
histone modification site profile
0.76
molecular function
0.7
transcription factor binding site profile
0.67
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.5   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.5   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
2
2
94.8
Alopecia
1
2
2
85.3
basophil count
3
2
3
85
myeloid white cell count
1
1
1
81.5
2
2
1
1.2
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
94.8
Alopecia
2
85.3
basophil count
3
85
myeloid white cell count
1
81.5
1
1.2
80.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
VGNC:9747
450804
Macaque
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
694105
Mouse
MGI:1923679
76429
Rat
RGD:1359187
361663
Dog
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
VGNC:42661
486930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Macaque
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Mouse
Rat
Dog
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H008-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (96)
1 – 10 of 96
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.974955557
p_ni:  0.025040344
p_wrong:  0.000004099
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.808303309
p_ni:  0.191696691
Data Source:  BioPlex
ATP4B
Tclin
Family:  Transporter
Novelty:  0.06924436
Score:  0.928
Data Source:  STRINGDB
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
Score:  0.922
Data Source:  STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
Score:  0.922
Data Source:  STRINGDB
PPA1
Tbio
Family:  Enzyme
Novelty:  0.00109986
Score:  0.903
Data Source:  STRINGDB
ATP6V0A4
Tbio
Family:  Enzyme
Novelty:  0.01534041
Score:  0.857
Data Source:  STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
Score:  0.856
Data Source:  STRINGDB
ATP5MC3
Tdark
Family:  Enzyme
Novelty:  0.04850603
Score:  0.801
Data Source:  STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.8
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.50

PubMed score by year
PubTator Score  6.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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