UBA5
Ubiquitin-like modifier-activating enzyme 5
Protein Summary
E1-like enzyme which activates UFM1 and SUMO2. This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]
- ENST00000264991
- ENSP00000264991
- ENSG00000081307
- ENST00000356232
- ENSP00000348565
- ENST00000494238
- ENSP00000418807
- UBE1DC1
- EIEE44
- SCAR24
- THIFP1
- UBE1DC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
molecular function | 0.91 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.68 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.38 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.38 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0