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Tbio
UBA5
Ubiquitin-like modifier-activating enzyme 5

Protein Summary
Description
E1-like enzyme which activates UFM1 and SUMO2. This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264991
  • ENSP00000264991
  • ENSG00000081307
  • ENST00000356232
  • ENSP00000348565
  • ENST00000494238
  • ENSP00000418807

Symbol
  • UBE1DC1
  • EIEE44
  • SCAR24
  • THIFP1
  • UBE1DC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.91
transcription factor perturbation
0.84
disease perturbation
0.68
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.76   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.76   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (312)
1 – 10 of 312
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.999999059
p_ni:  9.41e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
UFC1
Tbio
Novelty:  0.04181639
p_int:  0.998483177
p_ni:  0.001516823
Score:  0.976
Data Source:  BioPlex,STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
p_int:  0.998294699
p_ni:  0.001705301
Score:  0.784
Data Source:  BioPlex,STRINGDB
PECR
Tbio
Family:  Enzyme
Novelty:  0.01550165
p_int:  0.997951849
p_ni:  0.002048151
Score:  0.261
Data Source:  BioPlex,STRINGDB
REXO5
Tdark
Family:  Enzyme
Novelty:  0.8782494
p_int:  0.992369519
p_ni:  0.007630481
Score:  0.193
Data Source:  BioPlex,STRINGDB
BOLL
Tbio
Novelty:  0.02333312
p_int:  0.988448148
p_ni:  0.011551851
p_wrong:  1e-9
Score:  0.865
Data Source:  BioPlex,STRINGDB
UFM1
Tbio
Novelty:  0.0215914
p_int:  0.987091259
p_ni:  0.012908741
Score:  0.997
Data Source:  BioPlex,STRINGDB
MREG
Tbio
Novelty:  0.02056739
p_int:  0.983849665
p_ni:  0.016150335
Score:  0.234
Data Source:  BioPlex,STRINGDB
PNMA1
Tbio
Novelty:  0.06899807
p_int:  0.980282461
p_ni:  0.019717539
Score:  0.173
Data Source:  BioPlex,STRINGDB
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.979056509
p_ni:  0.019667983
p_wrong:  0.001275509
Score:  0.153
Data Source:  BioPlex,STRINGDB
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
63.1
apolipoprotein B measurement
1
1
1
60.5
total cholesterol measurement
1
1
1
51.4
alkaline phosphatase measurement
1
1
0
6.7
48.5
urate measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
63.1
apolipoprotein B measurement
1
60.5
total cholesterol measurement
1
51.4
alkaline phosphatase measurement
0
6.7
48.5
urate measurement
1
44.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 5
VGNC:7137
460705
Macaque
ubiquitin like modifier activating enzyme 5
717647
Mouse
MGI:1913913
66663
Rat
RGD:1311702
300968
Dog
ubiquitin like modifier activating enzyme 5
VGNC:48039
100856526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 5
Macaque
ubiquitin like modifier activating enzyme 5
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 5
Publication Statistics
PubMed Score 27.76
PubMed score by year
PubTator Score 15.44
PubTator score by year