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Tbio
UBA5
Ubiquitin-like modifier-activating enzyme 5

Protein Summary
Description
E1-like enzyme which activates UFM1 and SUMO2. This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264991
  • ENSP00000264991
  • ENSG00000081307
  • ENST00000356232
  • ENSP00000348565
  • ENST00000494238
  • ENSP00000418807

Symbol
  • UBE1DC1
  • EIEE44
  • SCAR24
  • THIFP1
  • UBE1DC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.91
transcription factor perturbation
0.84
disease perturbation
0.68
tissue sample
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.38   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.38   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0