You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CHRNA10
Neuronal acetylcholine receptor subunit alpha-10

Protein Classes
Protein Summary
Description
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250699
  • ENSP00000250699
  • ENSG00000129749

Symbol
  • NACHRA10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
tissue sample
0.71
drug
0.6
cell type or tissue
0.57


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 10 subunit
VGNC:7761
743844
Macaque
cholinergic receptor nicotinic alpha 10 subunit
718133
Mouse
MGI:3609260
504186
Rat
RGD:620142
64574
Horse
cholinergic receptor nicotinic alpha 10 subunit
VGNC:16523
100066301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 10 subunit
Macaque
cholinergic receptor nicotinic alpha 10 subunit
Mouse
Rat
Horse
cholinergic receptor nicotinic alpha 10 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZZ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Neuroactive ligand-receptor interaction
Name
Explore in Pharos
Explore in Source
Neuroactive ligand-receptor interaction
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (17)
1 – 10 of 17
KCNQ4
Tclin
Family:  IC
Novelty:  0.00626926
Score:  0.744
Data Source:  STRINGDB
CHAT
Tchem
Family:  Enzyme
Novelty:  0.00033026
Score:  0.712
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.694
Data Source:  STRINGDB
PGAP2
Tbio
Novelty:  0.06145169
Score:  0.65
Data Source:  STRINGDB
OTOF
Tbio
Novelty:  0.00676341
Score:  0.631
Data Source:  STRINGDB
ART5
Tbio
Family:  Enzyme
Novelty:  0.07566514
Score:  0.613
Data Source:  STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.571
Data Source:  STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
Score:  0.518
Data Source:  STRINGDB
USH1G
Tbio
Novelty:  0.02912203
Score:  0.514
Data Source:  STRINGDB
SLC25A15
Tbio
Family:  Transporter
Novelty:  0.01122054
Score:  0.512
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.01

PubMed score by year
PubTator Score  4.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer