Tchem NAA50 N-alpha-acetyltransferase 50

Protein Summary

Description

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821).

Uniprot Accession IDs

• Q9GZZ1
• D3DN74
• Q68DQ1
• hNaa50p

Gene Name

• NAA50

Ensembl ID

• ENST00000240922
• ENSP00000240922
• ENSG00000121579

Symbol

• MAK3
• NAT13
• NAT5
• SAN
• MAK3
• NAT5
• NAT13
• NAT5P
• NAT13P
• hNaa50p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
microRNA	0.87
histone modification site profile	0.84
transcription factor binding site profile	0.83
transcription factor	0.75

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 50

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 50

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.33   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.33   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0