You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MFF
Mitochondrial fission factor

Protein Summary
Description
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304593
  • ENSP00000304898
  • ENSG00000168958
  • ENST00000337110
  • ENSP00000338412
  • ENST00000349901
  • ENSP00000304134
  • ENST00000353339
  • ENSP00000302037
  • ENST00000354503
  • ENSP00000346498
  • ENST00000409565
  • ENSP00000386964
  • ENST00000409616
  • ENSP00000386641

Symbol
  • C2orf33
  • EMPF2
  • GL004
  • C2orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.97
biological process
0.79
cellular component
0.79
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.54   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.54   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
POTEKP
Tdark
p_int:  0.999999874
p_ni:  1.25e-7
p_wrong:  1e-9
Data Source:  BioPlex
CCDC126
Tdark
Novelty:  1.97527673
p_int:  0.999999078
p_ni:  9.07e-7
p_wrong:  1.5e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
TNFSF14
Tbio
Novelty:  0.01370893
p_int:  0.999757714
p_ni:  0.000021492
p_wrong:  0.000220794
Data Source:  BioPlex
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
p_int:  0.998333655
p_ni:  0.001666343
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
SPATA19
Tbio
Novelty:  0.06203122
p_int:  0.998080911
p_ni:  0.000010736
p_wrong:  0.001908352
Score:  0.305
Data Source:  BioPlex,STRINGDB
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.830751133
p_ni:  0.00013687
p_wrong:  0.169111997
Data Source:  BioPlex
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.951
Data Source:  STRINGDB
MIEF2
Tbio
Novelty:  0.04274587
Score:  0.905
Data Source:  STRINGDB
L0R8F8
Tbio
Novelty:  0.04096049
Score:  0.896
Data Source:  STRINGDB
Q9NQG6
Tbio
Novelty:  0.04096049
Score:  0.896
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
3
0
2.4
89.7
intraocular pressure measurement
2
3
3
80.7
hematocrit
1
1
1
53.7
3
1
0
1.3
52.7
albuminuria
2
1
0
1.2
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.4
89.7
intraocular pressure measurement
3
80.7
hematocrit
1
53.7
0
1.3
52.7
albuminuria
0
1.2
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission factor
VGNC:2015
459989
Macaque
mitochondrial fission factor
708489
Mouse
MGI:1922984
75734
Rat
RGD:1310230
301563
Horse
mitochondrial fission factor
VGNC:20143
100056853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission factor
Macaque
mitochondrial fission factor
Mouse
Rat
Horse
mitochondrial fission factor
Publication Statistics
PubMed Score 245.54
PubMed score by year
PubTator Score 26.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title