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Tbio
MFF
Mitochondrial fission factor

Protein Summary
Description
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304593
  • ENSP00000304898
  • ENSG00000168958
  • ENST00000337110
  • ENSP00000338412
  • ENST00000349901
  • ENSP00000304134
  • ENST00000353339
  • ENSP00000302037
  • ENST00000354503
  • ENSP00000346498
  • ENST00000409565
  • ENSP00000386964
  • ENST00000409616
  • ENSP00000386641

Symbol
  • C2orf33
  • EMPF2
  • GL004
  • C2orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.97
biological process
0.79
cellular component
0.79
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.15   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.15   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
41.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
41.4
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (65)
1 – 10 of 65
POTEKP
Tdark
p_int: 0.999999874
p_ni: 1.25e-7
p_wrong: 1e-9
Data Source: BioPlex
CCDC126
Tdark
Novelty: 1.97527673
p_int: 0.999999078
p_ni: 9.07e-7
p_wrong: 1.5e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
TNFSF14
Tbio
Novelty: 0.01370893
p_int: 0.999757714
p_ni: 0.000021492
p_wrong: 0.000220794
Data Source: BioPlex
MGAT5
Tbio
Family: Enzyme
Novelty: 0.00707747
p_int: 0.998333655
p_ni: 0.001666343
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
SPATA19
Tbio
Novelty: 0.06203122
p_int: 0.998080911
p_ni: 0.000010736
p_wrong: 0.001908352
Score: 0.305
Data Source: BioPlex,STRINGDB
DDHD1
Tbio
Family: Enzyme
Novelty: 0.05209502
p_int: 0.830751133
p_ni: 0.00013687
p_wrong: 0.169111997
Data Source: BioPlex
DNM1L
Tbio
Novelty: 0.00151314
Score: 0.951
Data Source: STRINGDB
MIEF2
Tbio
Novelty: 0.04274587
Score: 0.905
Data Source: STRINGDB
MIEF1
Tbio
Novelty: 0.04096049
Score: 0.896
Data Source: STRINGDB
MIEF1
Tbio
Novelty: 0.04096049
Score: 0.896
Data Source: STRINGDB
Publication Statistics
PubMed Score  233.15

PubMed score by year
PubTator Score  26.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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