LAT2
Linker for activation of T-cells family member 2
Protein Summary
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000275635
- ENSP00000275635
- ENSG00000086730
- ENST00000344995
- ENSP00000344881
- ENST00000398475
- ENSP00000381492
- ENST00000460943
- ENSP00000420494
- ENST00000488266
- ENSP00000433807
- LAB
- NTAL
- WBS15
- WBSCR15
- WBSCR5
- LAB
- NTAL
- WSCR5
- WBSCR5
- HSPC046
- WBSCR15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
cellular component | 0.77 | ||
kinase perturbation | 0.76 | ||
transcription factor perturbation | 0.74 | ||
phenotype | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.69 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 464 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.69 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 464 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fc epsilon receptor (FCERI) signaling | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Role of LAT2/NTAL/LAB on calcium mobilization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fc epsilon receptor (FCERI) signaling | ||||
Immune System | ||||
Innate Immune System | ||||
Role of LAT2/NTAL/LAB on calcium mobilization | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | HGNC | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 1 | 1 | 1 | 40.7 | |||||
2 | 2 | 0 | 1.6 | 32.8 | |||||
1 | 1 | 0 | 1.5 | 7.1 | |||||
1 | 1 | 0 | 1.5 | 7.1 | |||||
1 | 1 | 0 | 1.5 | 7.1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum non-albumin protein measurement | 1 | 40.7 | |||||
0 | 1.6 | 32.8 | |||||
0 | 1.5 | 7.1 | |||||
0 | 1.5 | 7.1 | |||||
0 | 1.5 | 7.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | linker for activation of T-cells family member 2 | 693676 | ||||||
Mouse | MGI:1926479 | 56743 | ||||||
Rat | RGD:631397 | 317676 | ||||||
Dog | linker for activation of T cells family member 2 | VGNC:42597 | 102156541 | |||||
Horse | linker for activation of T cells family member 2 | VGNC:19596 | 100062168 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | linker for activation of T-cells family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | linker for activation of T cells family member 2 | |||||
Horse | linker for activation of T cells family member 2 | |||||
Publication Statistics
PubMed Score 76.69
PubMed score by year
PubTator Score 87.06
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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