You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LAT2
Linker for activation of T-cells family member 2

Protein Summary
Description
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275635
  • ENSP00000275635
  • ENSG00000086730
  • ENST00000344995
  • ENSP00000344881
  • ENST00000398475
  • ENSP00000381492
  • ENST00000460943
  • ENSP00000420494
  • ENST00000488266
  • ENSP00000433807

Symbol
  • LAB
  • NTAL
  • WBS15
  • WBSCR15
  • WBSCR5
  • LAB
  • NTAL
  • WSCR5
  • WBSCR5
  • HSPC046
  • WBSCR15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
cellular component
0.77
kinase perturbation
0.76
transcription factor perturbation
0.74
phenotype
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.69   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.69   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
LAT
Tbio
Novelty:  0.00738419
Score:  0.973
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.969
Data Source:  Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.969
Data Source:  Reactome,STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.962
Data Source:  Reactome,STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.961
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.96
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.955
Data Source:  Reactome,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.947
Data Source:  Reactome,STRINGDB
GAB2
Tbio
Novelty:  0.00697372
Score:  0.932
Data Source:  Reactome,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.927
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Role of LAT2/NTAL/LAB on calcium mobilization
Name
Explore in Pharos
Explore in Source
Fc epsilon receptor (FCERI) signaling
Immune System
Innate Immune System
Role of LAT2/NTAL/LAB on calcium mobilization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
1
1
40.7
2
2
0
1.6
32.8
1
1
0
1.5
7.1
1
1
0
1.5
7.1
1
1
0
1.5
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
40.7
0
1.6
32.8
0
1.5
7.1
0
1.5
7.1
0
1.5
7.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
linker for activation of T-cells family member 2
693676
Mouse
MGI:1926479
56743
Rat
RGD:631397
317676
Dog
linker for activation of T cells family member 2
VGNC:42597
102156541
Horse
linker for activation of T cells family member 2
VGNC:19596
100062168
Species
Name
OMA
EggNOG
Inparanoid
Macaque
linker for activation of T-cells family member 2
Mouse
Rat
Dog
linker for activation of T cells family member 2
Horse
linker for activation of T cells family member 2
Publication Statistics
PubMed Score 76.69
PubMed score by year
PubTator Score 87.06
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title