LAT2
Linker for activation of T-cells family member 2
Protein Summary
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000275635
- ENSP00000275635
- ENSG00000086730
- ENST00000344995
- ENSP00000344881
- ENST00000398475
- ENSP00000381492
- ENST00000460943
- ENSP00000420494
- ENST00000488266
- ENSP00000433807
- LAB
- NTAL
- WBS15
- WBSCR15
- WBSCR5
- LAB
- NTAL
- WSCR5
- WBSCR5
- HSPC046
- WBSCR15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
cellular component | 0.77 | ||
kinase perturbation | 0.76 | ||
transcription factor perturbation | 0.74 | ||
phenotype | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.27 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 464 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.27 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 464 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0