Tbio COA1 Cytochrome c oxidase assembly factor 1 homolog

Protein Summary

Description

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.

Uniprot Accession IDs

• Q9GZY4
• A6NJU8
• A8KAH8
• Q9HAB7
• Q9NVD2

Gene Name

• COA1

Ensembl ID

• ENST00000223336
• ENSP00000223336
• ENSG00000106603
• ENST00000310564
• ENSP00000312100
• ENST00000395879
• ENSP00000379218
• ENST00000415076
• ENSP00000400759
• ENST00000438444
• ENSP00000395586
• ENST00000446330
• ENSP00000416406
• ENST00000446564
• ENSP00000413777

Symbol

• C7orf44
• MITRAC15
• C7orf44
• MITRAC15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.7
tissue sample	0.69
cellular component	0.68
co-expressed gene	0.57
transcription factor binding site profile	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0