Tbio AICDA Single-stranded DNA cytosine deaminase

Protein Summary

Description

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9GZX7
• Q6QJ81
• Q8NFC1

Gene Name

• AICDA

Ensembl ID

• ENST00000229335
• ENSP00000229335
• ENSG00000111732
• ENST00000537228
• ENSP00000445691

Symbol

• AID
• AID
• ARP2
• CDA2
• HIGM2
• HEL-S-284

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.97
biological process	0.93
biological term	0.76
kinase perturbation	0.66
hub protein	0.63

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Single-stranded Dna Cytosine Deaminase

Protein / Hydrolase / Deaminase / Single-stranded Dna Cytosine Deaminase

DTO Classes

Protein / Enzyme / Hydrolase / Deaminase / Single-stranded Dna Cytosine Deaminase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 738.87   (req: < 5)

Gene RIFs: 236   (req: <= 3)

Antibodies: 409   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 738.87   (req: >= 5)

Gene RIFs: 236   (req: > 3)

Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0