Protein Summary
Cytokine that contributes to the inflammatory response in vivo. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]
- ENST00000328087
- ENSP00000329384
- ENSG00000127318
- ENST00000538666
- ENSP00000442424
- ILTIF
- ZCYTO18
- TIFa
- IL-21
- IL-22
- ILTIF
- IL-TIF
- IL-D110
- zcyto18
- TIFIL-23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.96 | ||
phenotype | 0.79 | ||
protein domain | 0.58 | ||
small molecule perturbation | 0.58 | ||
disease | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 527.15 (req: < 5)
Gene RIFs: 277 (req: <= 3)
Antibodies: 876 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 527.15 (req: >= 5)
Gene RIFs: 277 (req: > 3)
Antibodies: 876 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (160)
Nearest Tclin Targets (18)
Upstream (1)
Downstream (17)
1 – 1 of 1
Pathways (10)
Reactome (4)
KEGG (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-20 family signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-20 family signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 1 | 1 | 48.5 | |||||
leukocyte count | 1 | 1 | 1 | 42.3 | |||||
lymphocyte count | 1 | 1 | 1 | 42.3 | |||||
vitamin D measurement | 2 | 1 | 2 | 8.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 48.5 | |||||
leukocyte count | 1 | 42.3 | |||||
lymphocyte count | 1 | 42.3 | |||||
vitamin D measurement | 2 | 8.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 22 | VGNC:5429 | 741423 | |||||
Macaque | interleukin 22 | 718047 | ||||||
Mouse | MGI:1355307 | 50929 | ||||||
Mouse | MGI:2151139 | 116849 | ||||||
Rat | RGD:1561292 | 500836 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 22 | |||||
Macaque | interleukin 22 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 527.15
PubMed score by year
PubTator Score 647.55
PubTator score by year
Related Publications
Text Mined References (296)
GeneRif Annotations (277)
Items per page:
0 of 0
PMID | Year | Title |
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