Tbio IL22 Interleukin-22

Protein Classes

DTO Classes

Interleukin-22 Receptor Subunit Alpha-2 / Interleukin-22 Receptor Subunit Alpha-1

Protein Summary

Description

Cytokine that contributes to the inflammatory response in vivo. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

Uniprot Accession IDs

• Q9GZX6
• IL-22

Gene Name

• IL22

Ensembl ID

• ENST00000328087
• ENSP00000329384
• ENSG00000127318
• ENST00000538666
• ENSP00000442424

Symbol

• ILTIF
• ZCYTO18
• TIFa
• IL-21
• IL-22
• ILTIF
• IL-TIF
• IL-D110
• zcyto18
• TIFIL-23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
phenotype	0.79
protein domain	0.58
small molecule perturbation	0.58
disease	0.56

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.87   (req: < 5)

Gene RIFs: 277   (req: <= 3)

Antibodies: 876   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.87   (req: >= 5)

Gene RIFs: 277   (req: > 3)

Antibodies: 876   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	2	1	2		17

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	2		17

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Protein Data Bank (6)

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (10)

Reactome (4)

KEGG (4)

WikiPathways (2)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-20 family signaling	26 targets	R-HSA-8854691
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-20 family signaling	26 targets	R-HSA-8854691
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (8)

Functions (2)

Components (2)

Processes (4)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
interleukin-22 receptor binding	Non-traceable Author Statement (NAS)	UniProtKB
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (160)

Explore Interacting Targets

1 – 10 of 160

• See Interactions on String-DB

IL22RA1

Tbio

Novelty: 0.01107638

Score: 0.998

Data Source: Reactome,STRINGDB

IL22RA2

Tbio

Novelty: 0.03455127

Score: 0.988

Data Source: Reactome,STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00011808

Score: 0.983

Data Source: Reactome,STRINGDB

IL10RB

Tbio

Novelty: 0.00880915

Score: 0.977

Data Source: Reactome,STRINGDB

STAT1

Tchem

Family: TF

Novelty: 0.0003383

Score: 0.97

Data Source: STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00074026

Score: 0.949

Data Source: STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00074178

Score: 0.948

Data Source: STRINGDB

TYK2

Tclin

Family: Kinase

Novelty: 0.00237955

Score: 0.948

Data Source: Reactome,STRINGDB

JAK1

Tclin

Family: Kinase

Novelty: 0.00093625

Score: 0.944

Data Source: Reactome,STRINGDB

IL10RA

Tbio

Novelty: 0.00506068

Score: 0.939

Data Source: STRINGDB

Publication Statistics

PubMed Score  502.87

PubMed score by year

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PubTator Score  647.55

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
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Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

vitamin D measurement

MGI Phenotype Find Similar Targets

cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype