Protein Classes
Protein Summary
Cytokine that contributes to the inflammatory response in vivo. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]
- ENST00000328087
- ENSP00000329384
- ENSG00000127318
- ENST00000538666
- ENSP00000442424
- ILTIF
- ZCYTO18
- TIFa
- IL-21
- IL-22
- ILTIF
- IL-TIF
- IL-D110
- zcyto18
- TIFIL-23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.96 | ||
phenotype | 0.79 | ||
protein domain | 0.58 | ||
small molecule perturbation | 0.58 | ||
disease | 0.56 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.87 (req: < 5)
Gene RIFs: 277 (req: <= 3)
Antibodies: 876 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 502.87 (req: >= 5)
Gene RIFs: 277 (req: > 3)
Antibodies: 876 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 2 | 1 | 2 | 17 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 2 | 17 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 22 | VGNC:5429 | 741423 | |||||
Macaque | interleukin 22 | 718047 | ||||||
Mouse | MGI:1355307 | 50929 | ||||||
Mouse | MGI:2151139 | 116849 | ||||||
Rat | RGD:1561292 | 500836 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 22 | |||||
Macaque | interleukin 22 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (10)
Reactome (4)
KEGG (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-20 family signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-20 family signaling | ||||
Signaling by Interleukins | ||||
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (160)
1 – 10 of 160
IL22RA1
Novelty: 0.01107638
Score: 0.998
Data Source: Reactome,STRINGDB
IL22RA2
Novelty: 0.03455127
Score: 0.988
Data Source: Reactome,STRINGDB
STAT3
Family: TF
Novelty: 0.00011808
Score: 0.983
Data Source: Reactome,STRINGDB
IL10RB
Novelty: 0.00880915
Score: 0.977
Data Source: Reactome,STRINGDB
STAT1
Family: TF
Novelty: 0.0003383
Score: 0.97
Data Source: STRINGDB
STAT5A
Family: TF
Novelty: 0.00074026
Score: 0.949
Data Source: STRINGDB
STAT5B
Family: TF
Novelty: 0.00074178
Score: 0.948
Data Source: STRINGDB
TYK2
Family: Kinase
Novelty: 0.00237955
Score: 0.948
Data Source: Reactome,STRINGDB
JAK1
Family: Kinase
Novelty: 0.00093625
Score: 0.944
Data Source: Reactome,STRINGDB
IL10RA
Novelty: 0.00506068
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score 502.87
PubMed score by year
PubTator Score 647.55
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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