Tbio IL22 Interleukin-22

Protein Summary

Description

Cytokine that contributes to the inflammatory response in vivo. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

Uniprot Accession IDs

• Q9GZX6
• IL-22

Gene Name

• IL22

Ensembl ID

• ENST00000328087
• ENSP00000329384
• ENSG00000127318
• ENST00000538666
• ENSP00000442424

Symbol

• ILTIF
• ZCYTO18
• TIFa
• IL-21
• IL-22
• ILTIF
• IL-TIF
• IL-D110
• zcyto18
• TIFIL-23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.96
phenotype	0.79
protein domain	0.58
small molecule perturbation	0.58
disease	0.56

Protein Classes

DTO Classes

Interleukin-22 Receptor Subunit Alpha-2 / Interleukin-22 Receptor Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.43   (req: < 5)

Gene RIFs: 383   (req: <= 3)

Antibodies: 876   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.43   (req: >= 5)

Gene RIFs: 383   (req: > 3)

Antibodies: 876   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0