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Tclin
FGF23
Fibroblast growth factor 23

Protein Summary
Description
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237837
  • ENSP00000237837
  • ENSG00000118972

Symbol
  • HYPF
  • ADHR
  • FGFN
  • HYPF
  • HFTC2
  • HPDR2
  • PHPTC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
biological process
0.96
phenotype
0.72
cell line
0.65
pathway
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2793.01   (req: < 5)
Gene RIFs: 426   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2793.01   (req: >= 5)
Gene RIFs: 426   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
KL
Tbio
Family:  Enzyme
Novelty:  0.00096954
Score:  0.999
Data Source:  Reactome,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.996
Data Source:  Reactome,STRINGDB
GALNT3
Tbio
Family:  Enzyme
Novelty:  0.01140808
Score:  0.991
Data Source:  Reactome,STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.985
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.985
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.984
Data Source:  STRINGDB
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.983
Data Source:  STRINGDB
DMP1
Tbio
Novelty:  0.03114505
Score:  0.982
Data Source:  STRINGDB
MEPE
Tbio
Novelty:  0.00825085
Score:  0.978
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (157)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 78
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
2
1.3
98.6
sex hormone-binding globulin measurement
6
1
6
87.6
appendicular lean mass
3
1
3
87.4
2
2
0
1.1
83
1
2
0
1.1
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.3
98.6
sex hormone-binding globulin measurement
6
87.6
appendicular lean mass
3
87.4
0
1.1
83
0
1.1
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 23
VGNC:5380
747164
Mouse
MGI:1891427
64654
Rat
RGD:620178
170583
Dog
fibroblast growth factor 23
VGNC:54303
611773
Horse
fibroblast growth factor 23
VGNC:18017
100058460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 23
Mouse
Rat
Dog
fibroblast growth factor 23
Horse
fibroblast growth factor 23
Publication Statistics
PubMed Score 2793.01
PubMed score by year
PubTator Score 1587.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title