Tclin FGF23 Fibroblast growth factor 23

Protein Summary

Description

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• Q9GZV9
• Q4V758
• FGF-23

Gene Name

• FGF23

Ensembl ID

• ENST00000237837
• ENSP00000237837
• ENSG00000118972

Symbol

• HYPF
• ADHR
• FGFN
• HYPF
• HFTC2
• HPDR2
• PHPTC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
biological process	0.96
phenotype	0.72
cell line	0.65
pathway	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 23

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3134.53   (req: < 5)

Gene RIFs: 617   (req: <= 3)

Antibodies: 462   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3134.53   (req: >= 5)

Gene RIFs: 617   (req: > 3)

Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1