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Tbio
PRDM14
PR domain zinc finger protein 14

Protein Summary
Description
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276594
  • ENSP00000276594
  • ENSG00000147596

Symbol
  • PFM11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
gene perturbation
0.74
PubMedID
0.65
cell line
0.64
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.1   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.1   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
29.9
1
1
0
1.1
24.1
1
1
0
1.1
15.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
29.9
0
1.1
24.1
0
1.1
15.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 14
VGNC:13234
464224
Mouse
MGI:3588194
383491
Rat
RGD:2319590
100365184
Dog
PR/SET domain 14
VGNC:44946
100855816
Horse
PR/SET domain 14
VGNC:21814
100062473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 14
Mouse
Rat
Dog
PR/SET domain 14
Horse
PR/SET domain 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZV8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (96)
1 – 10 of 96
CBFA2T2
Tbio
Novelty: 0.06262074
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
RUNX1T1
Tbio
Novelty: 0.0039633
p_int: 0.99999998
p_ni: 1e-8
p_wrong: 1e-8
Score: 0.428
Data Source: BioPlex,STRINGDB
STRIP2
Tbio
Novelty: 0.19321125
p_int: 0.99999813
p_ni: 0.00000187
Score: 0.206
Data Source: BioPlex,STRINGDB
PRDM6
Tbio
Family: TF; Epigenetic
Novelty: 0.04172889
p_int: 0.999993971
p_ni: 6.16e-7
p_wrong: 0.000005413
Score: 0.854
Data Source: BioPlex,STRINGDB
CBFA2T3
Tbio
Novelty: 0.01235845
p_int: 0.99996719
p_ni: 5.3e-8
p_wrong: 0.000032757
Score: 0.595
Data Source: BioPlex,STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
p_int: 0.999947376
p_ni: 0.000052624
Data Source: BioPlex
CTTNBP2NL
Tbio
Novelty: 0.52774527
p_int: 0.999942384
p_ni: 0.000057616
Data Source: BioPlex
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.999342401
p_ni: 0.000657599
Data Source: BioPlex
STRN4
Tbio
Novelty: 0.09936184
p_int: 0.999227649
p_ni: 0.000772351
Data Source: BioPlex
STRN
Tbio
Novelty: 0.01025814
p_int: 0.999094523
p_ni: 0.000905477
Data Source: BioPlex
Publication Statistics
PubMed Score  73.10

PubMed score by year
PubTator Score  28.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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