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Tbio
WWTR1
WW domain-containing transcription regulator protein 1

Protein Summary
Description
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360632
  • ENSP00000353847
  • ENSG00000018408
  • ENST00000465804
  • ENSP00000419465
  • ENST00000467467
  • ENSP00000419234

Symbol
  • TAZ
  • TAZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.95
disease perturbation
0.93
kinase perturbation
0.93
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.04   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.04   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mental development measurement
1
1
0
6
53.8
body height
1
1
1
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mental development measurement
0
6
53.8
body height
1
34.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WW domain containing transcription regulator 1
VGNC:2630
460772
Mouse
MGI:1917649
97064
Rat
RGD:1559609
295062
Dog
WW domain containing transcription regulator 1
VGNC:52910
609743
Horse
WW domain containing transcription regulator 1
VGNC:25062
100050661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WW domain containing transcription regulator 1
Mouse
Rat
Dog
WW domain containing transcription regulator 1
Horse
WW domain containing transcription regulator 1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Gene expression (Transcription)
Generic Transcription Pathway
Muscle contraction
Physiological factors
Protein-Protein Interactions (140)
1 – 10 of 140
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
p_int: 1
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
p_int: 0.999999984
p_wrong: 1.6e-8
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
p_int: 0.99999911
p_ni: 8.85e-7
p_wrong: 5e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
TEAD3
Tbio
Family: TF
Novelty: 0.04014337
p_int: 0.999949264
p_ni: 2.4e-8
p_wrong: 0.000050712
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.986977648
p_ni: 0.000016411
p_wrong: 0.013005941
Score: 0.66
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.877821445
p_ni: 0.122178554
Score: 0.904
Data Source: BioPlex,STRINGDB
LATS1
Tbio
Family: Kinase
Novelty: 0.00369058
Score: 0.991
Data Source: Reactome,STRINGDB
AMOTL1
Tbio
Novelty: 0.03842225
Score: 0.986
Data Source: Reactome,STRINGDB
CTGF
Tbio
Novelty: 0.0004346
Score: 0.981
Data Source: STRINGDB
LATS2
Tchem
Family: Kinase
Novelty: 0.00521035
Score: 0.978
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  289.04

PubMed score by year
PubTator Score  64.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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