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Tbio
EIF5A2
Eukaryotic translation initiation factor 5A-2

Protein Summary
Description
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295822
  • ENSP00000295822
  • ENSG00000163577

Symbol
  • EIF-5A2
  • eIF5AII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
protein domain
0.85
interacting protein
0.82
microRNA
0.78
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.98   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.98   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
4
6
6
96.9
HbA1c measurement
4
4
5
89.6
C-reactive protein measurement
2
3
3
81.1
2
2
1
1.1
79.1
body mass index
2
2
2
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
6
96.9
HbA1c measurement
5
89.6
C-reactive protein measurement
3
81.1
1
1.1
79.1
body mass index
2
71.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 5A2
695647
Mouse
MGI:1933735
208691
Rat
RGD:1306196
310261
Dog
eukaryotic translation initiation factor 5A2
VGNC:40293
488164
Horse
eukaryotic translation initiation factor 5A2
VGNC:17511
100064019
Species
Name
OMA
EggNOG
Inparanoid
Macaque
eukaryotic translation initiation factor 5A2
Mouse
Rat
Dog
eukaryotic translation initiation factor 5A2
Horse
eukaryotic translation initiation factor 5A2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZV4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Hypusine synthesis from eIF5A-lysine
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Hypusine synthesis from eIF5A-lysine
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (196)
1 – 10 of 196
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.999999571
p_ni:  4.29e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DOHH
Tbio
Family:  Enzyme
Novelty:  0.02313651
p_int:  0.999999495
p_ni:  5.05e-7
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
EIF5A
Tbio
Novelty:  0.00654932
p_int:  0.999868827
p_ni:  0.000131173
Score:  0.902
Data Source:  BioPlex,STRINGDB
PIK3C2A
Tchem
Family:  Kinase
Novelty:  0.0002219
p_int:  0.999842883
p_ni:  0.000157056
p_wrong:  6.1e-8
Data Source:  BioPlex
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.998186267
p_ni:  0.001726379
p_wrong:  0.000087354
Data Source:  BioPlex
PDCD2L
Tbio
Novelty:  0.33193498
p_int:  0.997776459
p_ni:  0.002212471
p_wrong:  0.00001107
Data Source:  BioPlex
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
p_int:  0.996595965
p_wrong:  0.003404035
Data Source:  BioPlex
GINS1
Tbio
Novelty:  0.08722396
p_int:  0.983827467
p_ni:  0.016172531
p_wrong:  2e-9
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.951550672
p_ni:  0.000074359
p_wrong:  0.048374969
Data Source:  BioPlex
TRMT2B
Tbio
Family:  Enzyme
Novelty:  0.12373575
p_int:  0.878169574
p_ni:  0.038236415
p_wrong:  0.083594011
Data Source:  BioPlex
Publication Statistics
PubMed Score  89.98

PubMed score by year
PubTator Score  56.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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