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Tbio
ANKRD2
Ankyrin repeat domain-containing protein 2

Protein Summary
Description
Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298808
  • ENSP00000298808
  • ENSG00000165887
  • ENST00000307518
  • ENSP00000306163

Symbol
  • ARPP
  • ARPP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
cell type or tissue
0.84
gene perturbation
0.84
small molecule perturbation
0.58
biological process
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
MICB
Tbio
Novelty:  0.00364639
p_int:  0.99994712
p_ni:  0.00005288
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.885
Data Source:  STRINGDB
YBX1
Tbio
Family:  TF
Novelty:  0.00132108
Score:  0.828
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.773
Data Source:  STRINGDB
TCAP
Tbio
Novelty:  0.00623581
Score:  0.732
Data Source:  STRINGDB
MYOD1
Tbio
Family:  TF
Novelty:  0.00053412
Score:  0.702
Data Source:  STRINGDB
CSRP3
Tbio
Novelty:  0.00892632
Score:  0.694
Data Source:  STRINGDB
MYPN
Tbio
Novelty:  0.03041873
Score:  0.629
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.624
Data Source:  STRINGDB
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
55.2
blood metabolite measurement
1
1
1
40.7
amino acid measurement
1
1
1
40.7
protein measurement
1
1
1
40.7
BMI-adjusted waist circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
55.2
blood metabolite measurement
1
40.7
amino acid measurement
1
40.7
protein measurement
1
40.7
BMI-adjusted waist circumference
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 2
VGNC:7218
450655
Macaque
ankyrin repeat domain 2
707097
Mouse
MGI:1861447
56642
Rat
RGD:1305104
309374
Dog
ankyrin repeat domain 2
VGNC:37889
486822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 2
Macaque
ankyrin repeat domain 2
Mouse
Rat
Dog
ankyrin repeat domain 2
Publication Statistics
PubMed Score 51.32
PubMed score by year
PubTator Score 16.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title