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Tdark
FAM192A
PSME3-interacting protein

Protein Summary
Description
Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309137
  • ENSP00000335808
  • ENSG00000172775
  • ENST00000389447
  • ENSP00000374098
  • ENST00000564108
  • ENSP00000456211
  • ENST00000567439
  • ENSP00000457850
  • ENST00000569266
  • ENSP00000457740

Symbol
  • C16orf94
  • NIP30
  • PIP30
  • CDA10
  • NIP30
  • PIP30
  • CDA018
  • C16orf94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.96
cell type or tissue
0.91
disease perturbation
0.9
histone modification site profile
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
12
12
97.8
apolipoprotein A 1 measurement
2
8
8
95.7
mean corpuscular hemoglobin concentration
2
2
2
57.1
sleep duration
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
97.8
apolipoprotein A 1 measurement
8
95.7
mean corpuscular hemoglobin concentration
2
57.1
sleep duration
1
11.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 192 member A
VGNC:5761
454112
Mouse
MGI:1919637
102122
Rat
RGD:1307433
307652
Dog
family with sequence similarity 192 member A
VGNC:40640
478114
Horse
family with sequence similarity 192 member A
VGNC:17835
100062226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 192 member A
Mouse
Rat
Dog
family with sequence similarity 192 member A
Horse
family with sequence similarity 192 member A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.99982767
p_ni:  0.00017233
Data Source:  BioPlex
RASL10B
Tdark
Family:  Enzyme
Novelty:  0.36095886
p_int:  0.999547746
p_ni:  0.000452254
Score:  0.239
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.99942035
p_ni:  0.00057965
Score:  0.889
Data Source:  BioPlex,STRINGDB
RAB40AL
Tbio
Novelty:  0.00908832
p_int:  0.998417147
p_ni:  0.001582852
p_wrong:  1e-9
Score:  0.787
Data Source:  BioPlex,STRINGDB
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.996665614
p_ni:  0.003334386
Score:  0.223
Data Source:  BioPlex,STRINGDB
FAM218A
Tdark
Novelty:  10.69354839
p_int:  0.991826378
p_ni:  0.008173622
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.985103779
p_ni:  0.014896213
p_wrong:  9e-9
Data Source:  BioPlex
IL17RE
Tbio
Novelty:  0.07568341
p_int:  0.983303707
p_ni:  0.016696293
Score:  0.173
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.979102541
p_ni:  0.020897459
Score:  0.205
Data Source:  BioPlex,STRINGDB
CAMTA2
Tbio
Family:  TF
Novelty:  0.06741618
p_int:  0.976386315
p_ni:  0.023613685
Score:  0.864
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.27

PubMed score by year
PubTator Score  2.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer