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Tdark
FAM192A
PSME3-interacting protein

Protein Summary
Description
Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309137
  • ENSP00000335808
  • ENSG00000172775
  • ENST00000389447
  • ENSP00000374098
  • ENST00000564108
  • ENSP00000456211
  • ENST00000567439
  • ENSP00000457850
  • ENST00000569266
  • ENSP00000457740

Symbol
  • C16orf94
  • NIP30
  • PIP30
  • CDA10
  • NIP30
  • PIP30
  • CDA018
  • C16orf94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.96
cell type or tissue
0.91
disease perturbation
0.9
histone modification site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0