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Tbio
CTDSP1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Protein Summary
Description
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273062
  • ENSP00000273062
  • ENSG00000144579
  • ENST00000443891
  • ENSP00000392248

Symbol
  • NIF3
  • NLIIF
  • SCP1
  • NIF3
  • SCP1
  • NLIIF
  • NLI-IF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
hub protein
0.71
transcription factor
0.71
histone modification site profile
0.64
biological process
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.59   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.59   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
71.2
sex hormone-binding globulin measurement
3
1
3
56.2
red blood cell density measurement
1
1
1
32.6
erythrocyte count
1
1
1
6.5
reticulocyte measurement
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
71.2
sex hormone-binding globulin measurement
3
56.2
red blood cell density measurement
1
32.6
erythrocyte count
1
6.5
reticulocyte measurement
1
5.7
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Coregulation of Androgen receptor activity
PathwayCommons: pid
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
PathwayCommons: pid
BMP receptor signaling
Name
Explore in Pharos
Explore in Source
Coregulation of Androgen receptor activity
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
BMP receptor signaling
Protein-Protein Interactions (53)
1 – 10 of 53
CDCA3
Tbio
Novelty: 0.05136899
p_int: 0.99999999
p_ni: 1e-8
Score: 0.766
Data Source: BioPlex,STRINGDB
CTDSP2
Tbio
Family: Enzyme
Novelty: 0.01033594
p_int: 0.999978429
p_wrong: 0.000021571
Score: 0.545
Data Source: BioPlex,STRINGDB
CTDSPL
Tbio
Family: Enzyme
Novelty: 0.00471423
p_int: 0.999968843
p_ni: 5.5e-8
p_wrong: 0.000031102
Score: 0.867
Data Source: BioPlex,STRINGDB
MBP
Tbio
Novelty: 0.00016333
p_int: 0.999740521
p_ni: 0.00023558
p_wrong: 0.000023899
Score: 0.812
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.997232528
p_ni: 0.00276747
p_wrong: 2e-9
Score: 0.166
Data Source: BioPlex,STRINGDB
DSTYK
Tchem
Family: Kinase
Novelty: 0.12049855
p_int: 0.981139915
p_ni: 0.018860085
Score: 0.232
Data Source: BioPlex,STRINGDB
FAM118B
Tdark
Novelty: 0.48168976
p_int: 0.979706862
p_ni: 0.01922213
p_wrong: 0.001071008
Score: 0.193
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.970127161
p_ni: 0.029872839
Score: 0.165
Data Source: BioPlex,STRINGDB
TUBA1A
Tchem
Novelty: 0.01030145
p_int: 0.96984764
p_ni: 0.03015236
Score: 0.175
Data Source: BioPlex,STRINGDB
TIMM10
Tbio
Family: Enzyme
Novelty: 0.02727463
p_int: 0.936766023
p_ni: 0.063233977
Score: 0.323
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  43.59

PubMed score by year
PubTator Score  20.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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