Protein Summary
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recogniz ...more
- ENST00000366641
- ENSP00000355601
- ENSG00000135766
- C1orf12
- HPH2
- PHD2
- SM20
- ECYT3
- HALAH
- HPH-2
- HIFPH2
- ZMYND6
- C1orf12
- HIF-PH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.93 | ||
biological process | 0.9 | ||
disease perturbation | 0.9 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 467.02 (req: < 5)
Gene RIFs: 117 (req: <= 3)
Antibodies: 546 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 467.02 (req: >= 5)
Gene RIFs: 117 (req: > 3)
Antibodies: 546 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 363
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (4)
Active Ligands (363)
Protein-Protein Interactions (184)
EEF1AKMT1
Family: Enzyme
Novelty: 0.22249584
p_int: 0.93056127
p_ni: 0.06943873
Score: 0.359
Data Source: BioPlex,STRINGDB
CBWD1
Novelty: 0.04321511
p_int: 0.817114935
p_ni: 0.182885064
p_wrong: 1e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (35)
Reactome (4)
KEGG (3)
PathwayCommons (4)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (5)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hematocrit | 4 | 5 | 6 | 98 | |||||
hemoglobin measurement | 4 | 5 | 6 | 97.9 | |||||
red blood cell density measurement | 2 | 2 | 2 | 93.2 | |||||
erythrocyte count | 1 | 2 | 2 | 83.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hematocrit | 6 | 98 | |||||
hemoglobin measurement | 6 | 97.9 | |||||
red blood cell density measurement | 2 | 93.2 | |||||
erythrocyte count | 2 | 83.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | egl-9 family hypoxia inducible factor 1 | VGNC:9857 | 469708 | |||||
Macaque | egl-9 family hypoxia inducible factor 1 | 713410 | ||||||
Mouse | MGI:1932286 | 112405 | ||||||
Dog | egl-9 family hypoxia inducible factor 1 | VGNC:40240 | 488971 | |||||
Horse | egl-9 family hypoxia inducible factor 1 | VGNC:51494 | 100060551 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | egl-9 family hypoxia inducible factor 1 | |||||
Macaque | egl-9 family hypoxia inducible factor 1 | |||||
Mouse | ||||||
Dog | egl-9 family hypoxia inducible factor 1 | |||||
Horse | egl-9 family hypoxia inducible factor 1 | |||||
Publication Statistics
PubMed Score 467.02
PubMed score by year
PubTator Score 257.47
PubTator score by year
Related Publications
Text Mined References (142)
GeneRif Annotations (117)
Items per page:
0 of 0
PMID | Year | Title |
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