Tbio SRR Serine racemase

Protein Summary

Description

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.

Uniprot Accession IDs

• Q9GZT4
• D3DTI5
• Q6IA55

Gene Name

• SRR

Ensembl ID

• ENST00000344595
• ENSP00000339435
• ENSG00000167720

Symbol

• ILV1
• ISO1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	1
virus perturbation	0.92
kinase perturbation	0.91
disease perturbation	0.9

Protein Classes

PANTHER Classes

Protein / Lyase / Dehydratase / Serine Racemase

Protein / Isomerase / Epimerase/racemase / Serine Racemase

Protein / Hydrolase / Deaminase / Serine Racemase

DTO Classes

Protein / Enzyme / Isomerase / Epimerase/racemase / Serine Racemase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.64   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.64   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

RNF41

Tbio

Family:  Enzyme

Novelty:  0.01953473

p_int:  0.999988404

p_ni:  0.000011596

Score:  0.213

Data Source:  BioPlex,STRINGDB

FCHO1

Tbio

Novelty:  0.10512826

p_int:  0.916075941

p_ni:  0.083924059

Score:  0.309

Data Source:  BioPlex,STRINGDB

OXNAD1

Tdark

Family:  Enzyme

Novelty:  1.38777329

p_int:  0.861311452

p_ni:  0.138688548

Score:  0.329

Data Source:  BioPlex,STRINGDB

SPACA1

Tbio

Novelty:  0.07415851

p_int:  0.775493158

p_ni:  0.224506841

p_wrong:  1e-9

Score:  0.171

Data Source:  BioPlex,STRINGDB

PSPH

Tbio

Family:  Enzyme

Novelty:  0.01078634

Score:  0.938

Data Source:  STRINGDB

SHMT1

Tbio

Family:  Enzyme

Novelty:  0.00200739

Score:  0.935

Data Source:  STRINGDB

SDS

Tbio

Family:  Enzyme

Novelty:  0.00482255

Score:  0.932

Data Source:  STRINGDB

SHMT2

Tchem

Family:  Enzyme

Novelty:  0.00234505

Score:  0.927

Data Source:  STRINGDB

SDSL

Tbio

Family:  Enzyme

Novelty:  0.02098867

Score:  0.925

Data Source:  STRINGDB

AGXT

Tbio

Family:  Enzyme

Novelty:  0.00267512

Score:  0.924

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

KEGG (2)

Metabolism (R-HSA-1430728)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Serine biosynthesis	9 targets	R-HSA-977347

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Serine biosynthesis	9 targets	R-HSA-977347

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (11)

Components (5)

Processes (11)

Find Similar Targets

Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
L-serine ammonia-lyase activity	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
pyridoxal phosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
serine racemase activity	Inferred from Direct Assay (IDA)	UniProtKB
PDZ domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
D-serine ammonia-lyase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
glycine binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (35)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 35

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	2	2		95
platelet crit	EFO_0007985	2	2	2		92.9
platelet count	EFO_0004309	2	2	2		89.9
coronary artery disease	EFO_0001645	2	3	1	1.1	84
lymphocyte count	EFO_0004587	1	1	1		79

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 35

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		95
platelet crit	EFO_0007985	2		92.9
platelet count	EFO_0004309	2		89.9
coronary artery disease	EFO_0001645	1	1.1	84
lymphocyte count	EFO_0004587	1		79

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Allosteric enzyme
ATP-binding
Complete proteome
Direct protein sequencing
Isomerase
Lyase
Magnesium
Metal-binding
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
aortic root size
autism spectrum disorder
balding measurement
BMI-adjusted hip circumference
body mass index
bone density
calcaneal bone quantitative ultrasound measurement
Cannabis use
comparative body size at age 10, self-reported

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serine racemase	VGNC:9655	747543
Macaque	small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026]
Mouse	serine racemase	MGI:1351636	27364
Rat	serine racemase	RGD:735094	303306
Horse	serine racemase	VGNC:23594	100060209

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serine racemase
Macaque	small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026]
Mouse	serine racemase
Rat	serine racemase
Horse	serine racemase

Publication Statistics

PubMed Score 245.64

PubMed score by year

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PubTator Score 144.35

PubTator score by year

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Related Publications

Text Mined References (50)

GeneRif Annotations (31)

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10

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PMID	Year	Title