Protein Summary
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
- ENST00000344595
- ENSP00000339435
- ENSG00000167720
- ILV1
- ISO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.92 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.64 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.64 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (67)
RNF41
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999988404
p_ni: 0.000011596
Score: 0.213
Data Source: BioPlex,STRINGDB
FCHO1
Novelty: 0.10512826
p_int: 0.916075941
p_ni: 0.083924059
Score: 0.309
Data Source: BioPlex,STRINGDB
OXNAD1
Family: Enzyme
Novelty: 1.38777329
p_int: 0.861311452
p_ni: 0.138688548
Score: 0.329
Data Source: BioPlex,STRINGDB
SPACA1
Novelty: 0.07415851
p_int: 0.775493158
p_ni: 0.224506841
p_wrong: 1e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Serine biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Serine biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (11)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 2 | 2 | 95 | |||||
platelet crit | 2 | 2 | 2 | 92.9 | |||||
platelet count | 2 | 2 | 2 | 89.9 | |||||
2 | 3 | 1 | 1.1 | 84 | |||||
lymphocyte count | 1 | 1 | 1 | 79 | |||||
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 95 | |||||
platelet crit | 2 | 92.9 | |||||
platelet count | 2 | 89.9 | |||||
1 | 1.1 | 84 | |||||
lymphocyte count | 1 | 79 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | serine racemase | VGNC:9655 | 747543 | |||||
Macaque | small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026] | |||||||
Mouse | MGI:1351636 | 27364 | ||||||
Rat | RGD:735094 | 303306 | ||||||
Horse | serine racemase | VGNC:23594 | 100060209 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | serine racemase | |||||
Macaque | small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026] | |||||
Mouse | ||||||
Rat | ||||||
Horse | serine racemase | |||||
Publication Statistics
PubMed Score 245.64
PubMed score by year
PubTator Score 144.35
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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