Protein Classes
Protein Summary
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
- ENST00000344595
- ENSP00000339435
- ENSG00000167720
- ILV1
- ISO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.92 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.64 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.64 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.3 | 64.7 | |||||
4 | 1 | 0 | 1.1 | 52.8 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 44.5 | |||||
1 | 1 | 0 | 1.1 | 22.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 64.7 | |||||
0 | 1.1 | 52.8 | |||||
alcohol consumption measurement | 1 | 44.5 | |||||
0 | 1.1 | 22.6 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine racemase | VGNC:9655 | 747543 | |||||
Macaque | small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026] | |||||||
Mouse | MGI:1351636 | 27364 | ||||||
Rat | RGD:735094 | 303306 | ||||||
Horse | serine racemase | VGNC:23594 | 100060209 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine racemase | |||||
Macaque | small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026] | |||||
Mouse | ||||||
Rat | ||||||
Horse | serine racemase | |||||
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Serine biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Serine biosynthesis | ||||
Gene Ontology Terms (27)
Functions (11)
Components (5)
Processes (11)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (67)
1 – 10 of 67
RNF41
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999988404
p_ni: 0.000011596
Score: 0.213
Data Source: BioPlex,STRINGDB
FCHO1
Novelty: 0.10512826
p_int: 0.916075941
p_ni: 0.083924059
Score: 0.309
Data Source: BioPlex,STRINGDB
OXNAD1
Family: Enzyme
Novelty: 1.38777329
p_int: 0.861311452
p_ni: 0.138688548
Score: 0.329
Data Source: BioPlex,STRINGDB
SPACA1
Novelty: 0.07415851
p_int: 0.775493158
p_ni: 0.224506841
p_wrong: 1e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
PSPH
Family: Enzyme
Novelty: 0.01078634
Score: 0.938
Data Source: STRINGDB
SHMT1
Family: Enzyme
Novelty: 0.00200739
Score: 0.935
Data Source: STRINGDB
SDS
Family: Enzyme
Novelty: 0.00482255
Score: 0.932
Data Source: STRINGDB
SHMT2
Family: Enzyme
Novelty: 0.00234505
Score: 0.927
Data Source: STRINGDB
SDSL
Family: Enzyme
Novelty: 0.02098867
Score: 0.925
Data Source: STRINGDB
AGXT
Family: Enzyme
Novelty: 0.00267512
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score 241.64
PubMed score by year
PubTator Score 144.35
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait