Protein Summary
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
- ENST00000344595
- ENSP00000339435
- ENSG00000167720
- ILV1
- ISO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.92 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 298.78 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 298.78 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0