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Tbio
SRR
Serine racemase

Protein Summary
Description
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344595
  • ENSP00000339435
  • ENSG00000167720

Symbol
  • ILV1
  • ISO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
1
virus perturbation
0.92
kinase perturbation
0.91
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.64   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.64   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
64.7
4
1
0
1.1
52.8
alcohol consumption measurement
1
1
1
44.5
1
1
0
1.1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
64.7
0
1.1
52.8
alcohol consumption measurement
1
44.5
0
1.1
22.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine racemase
VGNC:9655
747543
Macaque
small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026]
Mouse
MGI:1351636
27364
Rat
RGD:735094
303306
Horse
serine racemase
VGNC:23594
100060209
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine racemase
Macaque
small G protein signaling modulator 2 [Source:HGNC Symbol;Acc:HGNC:29026]
Mouse
Rat
Horse
serine racemase
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999988404
p_ni: 0.000011596
Score: 0.213
Data Source: BioPlex,STRINGDB
FCHO1
Tbio
Novelty: 0.10512826
p_int: 0.916075941
p_ni: 0.083924059
Score: 0.309
Data Source: BioPlex,STRINGDB
OXNAD1
Tdark
Family: Enzyme
Novelty: 1.38777329
p_int: 0.861311452
p_ni: 0.138688548
Score: 0.329
Data Source: BioPlex,STRINGDB
SPACA1
Tbio
Novelty: 0.07415851
p_int: 0.775493158
p_ni: 0.224506841
p_wrong: 1e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
PSPH
Tbio
Family: Enzyme
Novelty: 0.01078634
Score: 0.938
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.935
Data Source: STRINGDB
SDS
Tbio
Family: Enzyme
Novelty: 0.00482255
Score: 0.932
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.927
Data Source: STRINGDB
SDSL
Tbio
Family: Enzyme
Novelty: 0.02098867
Score: 0.925
Data Source: STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00267512
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  241.64

PubMed score by year
PubTator Score  144.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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