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Tbio
SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

Protein Summary
Description
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238688
  • ENSP00000238688
  • ENSG00000119705
  • ENST00000557342
  • ENSP00000450909

Symbol
  • C14orf156
  • DC50
  • PD04872
  • C14orf156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
histone modification site profile
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.72
biological process
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.16   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.16   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
LRPPRC
Tbio
Novelty:  0.01573276
p_int:  0.999964689
p_ni:  0.000035311
Score:  0.955
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.999846518
p_ni:  0.000153481
p_wrong:  1e-9
Data Source:  BioPlex
MUC7
Tbio
Novelty:  0.00750654
p_int:  0.99974624
p_ni:  0.000203117
p_wrong:  0.000050642
Data Source:  BioPlex
ORC2
Tbio
Novelty:  0.11963517
p_int:  0.998368503
p_ni:  0.000120524
p_wrong:  0.001510973
Data Source:  BioPlex
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.995692937
p_ni:  0.004307063
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.993400743
p_ni:  0.006525876
p_wrong:  0.00007338
Data Source:  BioPlex
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
p_int:  0.982197613
p_ni:  0.017802387
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.952443082
p_ni:  0.047541906
p_wrong:  0.000015012
Data Source:  BioPlex
ECHDC2
Tdark
Family:  Enzyme
Novelty:  0.50396935
p_int:  0.934593497
p_ni:  0.065406502
p_wrong:  1e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.861746806
p_ni:  0.050778556
p_wrong:  0.087474638
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRA stem-loop interacting RNA binding protein
VGNC:12536
467519
Mouse
MGI:1916394
380773
Rat
RGD:1585290
688717
Dog
SRA stem-loop interacting RNA binding protein
VGNC:51688
490810
Horse
SRA stem-loop interacting RNA binding protein
VGNC:52441
100052429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRA stem-loop interacting RNA binding protein
Mouse
Rat
Dog
SRA stem-loop interacting RNA binding protein
Horse
SRA stem-loop interacting RNA binding protein
Publication Statistics
PubMed Score 23.16
PubMed score by year
PubTator Score 14.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title