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Tbio
WDR61
WD repeat-containing protein 61

Protein Summary
Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267973
  • ENSP00000267973
  • ENSG00000140395
  • ENST00000558311
  • ENSP00000453801

Symbol
  • SKI8
  • REC14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
kinase perturbation
0.95
biological process
0.88
disease perturbation
0.87
histone modification site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
54.7
red blood cell distribution width
1
1
1
50.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
54.7
red blood cell distribution width
1
50.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 61
VGNC:13456
453568
Macaque
WD repeat domain 61
709971
Mouse
MGI:1917493
66317
Rat
RGD:1308228
363064
Dog
WD repeat domain 61
479068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 61
Macaque
WD repeat domain 61
Mouse
Rat
Dog
WD repeat domain 61
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9GZS3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Metabolism of RNA
Gene Ontology Terms (18)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (232)
1 – 10 of 232
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.973063363
p_ni: 0.026936637
Score: 0.302
Data Source: BioPlex,STRINGDB
PAF1
Tbio
Family: Enzyme
Novelty: 0.00200047
p_int: 0.920149283
p_ni: 0.079850717
Score: 0.997
Data Source: BioPlex,STRINGDB
CDC73
Tbio
Novelty: 0.00362973
Score: 0.999
Data Source: STRINGDB
SKIV2L
Tbio
Family: Enzyme
Novelty: 0.01108539
Score: 0.998
Data Source: Reactome,STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
Score: 0.998
Data Source: STRINGDB
TTC37
Tbio
Novelty: 0.02816322
Score: 0.998
Data Source: Reactome,STRINGDB
LEO1
Tbio
Family: Enzyme
Novelty: 0.00851903
Score: 0.998
Data Source: STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.989
Data Source: STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
Score: 0.984
Data Source: STRINGDB
HBS1L
Tbio
Novelty: 0.00125579
Score: 0.981
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  61.82

PubMed score by year
PubTator Score  4.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer