Tbio POLR1E DNA-directed RNA polymerase I subunit RPA49

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).

Uniprot Accession IDs

• Q9GZS1
• Q5VZT3
• Q8NBA9
• Q96L20
• RNA polymerase I subunit A49

Gene Name

• POLR1E

Ensembl ID

• ENST00000377792
• ENSP00000367023
• ENSG00000137054
• ENST00000377798
• ENSP00000367029

Symbol

• PAF53
• PRAF1
• PAF53
• PRAF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
disease perturbation	0.79
transcription factor binding site profile	0.7
histone modification site profile	0.67
protein complex	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0