Tbio DNAI2 Dynein intermediate chain 2, axonemal

Protein Summary

Description

Part of the dynein complex of respiratory cilia. The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9GZS0
• C9J0S6
• Q8IUW4
• Q9H179
• Q9NT53

Gene Name

• DNAI2

Ensembl ID

• ENST00000311014
• ENSP00000308312
• ENSG00000171595
• ENST00000446837
• ENSP00000400252
• ENST00000582036
• ENSP00000461950

Symbol

• DIC2
• CILD9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.64
cell type or tissue	0.52
tissue	0.52
transcription factor	0.52
cellular component	0.5

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynein Intermediate Chain 2, Axonemal

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Dynein Intermediate Chain 2, Axonemal

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.03   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.03   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0