Tbio ELOVL4 Elongation of very long chain fatty acids protein 4

Protein Summary

Description

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9GZR5
• B2R6B5
• Q5TCS2
• Q86YJ1
• Q9H139

Gene Name

• ELOVL4

Ensembl ID

• ENST00000369816
• ENSP00000358831
• ENSG00000118402

Symbol

• ADMD
• CT118
• ISQMR
• SCA34
• STGD2
• STGD3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.73
microRNA	0.68
histone modification site profile	0.66
kinase perturbation	0.66
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 4

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Elongation Of Very Long Chain Fatty Acids Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.79   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.79   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0