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Tbio
ELOVL4
Elongation of very long chain fatty acids protein 4

Protein Summary
Description
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369816
  • ENSP00000358831
  • ENSG00000118402

Symbol
  • ADMD
  • CT118
  • ISQMR
  • SCA34
  • STGD2
  • STGD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.73
microRNA
0.68
histone modification site profile
0.66
kinase perturbation
0.66
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.55   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.55   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ELOVL fatty acid elongase 4
692070
Mouse
MGI:1933331
83603
Rat
RGD:1305630
315851
Dog
ELOVL fatty acid elongase 4
VGNC:40322
481894
Horse
ELOVL fatty acid elongase 4
VGNC:17540
100069512
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ELOVL fatty acid elongase 4
Mouse
Rat
Dog
ELOVL fatty acid elongase 4
Horse
ELOVL fatty acid elongase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZR5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (58)
1 – 10 of 58
SLC7A14
Tbio
Family: Transporter
Novelty: 0.1613451
p_int: 0.924875674
p_ni: 0.006192131
p_wrong: 0.068932195
Data Source: BioPlex
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.817840709
p_ni: 0.032923206
p_wrong: 0.149236086
Score: 0.244
Data Source: BioPlex,STRINGDB
HSD17B12
Tbio
Family: Enzyme
Novelty: 0.02200219
Score: 0.963
Data Source: STRINGDB
IMPG1
Tbio
Novelty: 0.03770903
Score: 0.93
Data Source: STRINGDB
TENT5A
Tbio
Novelty: 0.08412895
Score: 0.906
Data Source: STRINGDB
ABCA4
Tbio
Family: Transporter
Novelty: 0.00162903
Score: 0.8
Data Source: STRINGDB
CERS3
Tbio
Family: TF
Novelty: 0.038629
Score: 0.666
Data Source: STRINGDB
LINS1
Tbio
Novelty: 0.00317377
Score: 0.663
Data Source: STRINGDB
CNGB3
Tchem
Family: IC
Novelty: 0.01174942
Score: 0.65
Data Source: STRINGDB
CLEC2D
Tbio
Novelty: 0.02501194
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  144.55

PubMed score by year
PubTator Score  76.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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