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Tbio
SENP6
Sentrin-specific protease 6

Protein Classes
Protein Summary
Description
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370010
  • ENSP00000359027
  • ENSG00000112701
  • ENST00000447266
  • ENSP00000402527

Symbol
  • KIAA0797
  • SSP1
  • SUSP1
  • SSP1
  • SUSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
virus perturbation
0.68
tissue sample
0.65
disease perturbation
0.62
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein sumoylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein sumoylation.
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
PRPF19
Tbio
Novelty: 0.01912462
p_int: 0.999999138
p_ni: 8.62e-7
Score: 0.665
Data Source: BioPlex,STRINGDB
ZDBF2
Tdark
Novelty: 0.17094017
p_int: 0.999486909
p_ni: 0.000513063
p_wrong: 2.8e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
FHL3
Tbio
Novelty: 0.20792079
p_int: 0.912030894
p_ni: 0.0004369
p_wrong: 0.087532206
Score: 0.222
Data Source: BioPlex,STRINGDB
SUMO2
Tbio
Novelty: 0.00437464
Score: 0.962
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00316288
Score: 0.909
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00169202
Score: 0.909
Data Source: STRINGDB
NKAIN2
Tbio
Family: Enzyme
Novelty: 0.04871448
Score: 0.903
Data Source: STRINGDB
SUMO4
Tbio
Novelty: 0.01875074
Score: 0.895
Data Source: STRINGDB
SUMO3
Tbio
Novelty: 0.0468487
Score: 0.89
Data Source: STRINGDB
UBA2
Tbio
Novelty: 0.02816874
Score: 0.857
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.65

PubMed score by year
PubTator Score  40.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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