Tbio MAP1LC3B Microtubule-associated proteins 1A/1B light chain 3B

Protein Summary

Description

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9GZQ8
• Q6NW02

Gene Name

• MAP1LC3B

Ensembl ID

• ENST00000268607
• ENSP00000268607
• ENSG00000140941

Symbol

• MAP1ALC3
• LC3B
• ATG8F
• MAP1LC3B-a
• MAP1A/1BLC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
kinase perturbation	1
transcription factor binding site profile	0.98
transcription factor perturbation	0.97

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Proteins 1a/1b Light Chain 3b

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Microtubule-associated Proteins 1a/1b Light Chain 3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1249.17   (req: < 5)

Gene RIFs: 116   (req: <= 3)

Antibodies: 1042   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1249.17   (req: >= 5)

Gene RIFs: 116   (req: > 3)

Antibodies: 1042   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0