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Tchem
NPFFR1
Neuropeptide FF receptor 1

Protein Summary
Description
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277942
  • ENSP00000277942
  • ENSG00000148734

Symbol
  • GPR147
  • NPFF1
  • NPFF1
  • GPR147
  • NPFF1R1
  • OT7T022
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
ligand (protein)
0.68
small molecule perturbation
0.6
protein domain
0.58
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0