Tchem NPFFR1 Neuropeptide FF receptor 1

Protein Summary

Description

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Uniprot Accession IDs

• Q9GZQ6
• A2RRF0
• Q8NGR0
• Q96RN3

Gene Name

• NPFFR1

Ensembl ID

• ENST00000277942
• ENSP00000277942
• ENSG00000148734

Symbol

• GPR147
• NPFF1
• NPFF1
• GPR147
• NPFF1R1
• OT7T022

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.7
ligand (protein)	0.68
small molecule perturbation	0.6
protein domain	0.58
cell line	0.53

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Neuropeptide Ff Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Neuropeptide Ff/neuropeptide Af Receptor / Neuropeptide Ff Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.53   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.53   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0