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Tchem
NMUR2
Neuromedin-U receptor 2

Protein Summary
Description
Receptor for the neuromedin-U and neuromedin-S neuropeptides. This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255262
  • ENSP00000255262
  • ENSG00000132911

Symbol
  • NMU2R
  • TGR1
  • FM4
  • FM-4
  • TGR1
  • NMU2R
  • TGR-1
  • NMU-R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.77
gene perturbation
0.71
protein domain
0.58
microRNA
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.3
42.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.3
42.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuromedin U receptor 2
VGNC:4101
471713
Macaque
neuromedin U receptor 2
714051
Mouse
MGI:2441765
216749
Rat
RGD:621155
64042
Dog
neuromedin U receptor 2
VGNC:43867
489170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuromedin U receptor 2
Macaque
neuromedin U receptor 2
Mouse
Rat
Dog
neuromedin U receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZQ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (409)
1 – 10 of 409
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
p_int: 0.999244941
p_ni: 0.000755058
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
SLC6A6
Tbio
Family: Transporter
Novelty: 0.00333868
p_int: 0.998729634
p_ni: 0.00035702
p_wrong: 0.000913346
Score: 0.216
Data Source: BioPlex,STRINGDB
SLC12A6
Tbio
Family: Transporter
Novelty: 0.0132619
p_int: 0.998128073
p_ni: 0.001871924
p_wrong: 3e-9
Score: 0.154
Data Source: BioPlex,STRINGDB
IGHA2
Tbio
p_int: 0.99698381
p_ni: 0.002995286
p_wrong: 0.000020904
Data Source: BioPlex
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
p_int: 0.973306074
p_ni: 0.026693926
Data Source: BioPlex
TYW1
Tbio
Family: Enzyme
Novelty: 0.05117274
p_int: 0.939463143
p_ni: 0.060536857
Data Source: BioPlex
TMEM63A
Tdark
Family: IC
Novelty: 0.33131011
p_int: 0.886259091
p_ni: 0.113554643
p_wrong: 0.000186266
Data Source: BioPlex
SLC41A3
Tdark
Family: Transporter
Novelty: 0.20246441
p_int: 0.875629073
p_ni: 0.00003209
p_wrong: 0.124338837
Score: 0.187
Data Source: BioPlex,STRINGDB
ADCK2
Tbio
Family: Kinase
Novelty: 0.13237052
p_int: 0.86451223
p_ni: 0.005746006
p_wrong: 0.129741763
Score: 0.163
Data Source: BioPlex,STRINGDB
ATP11C
Tbio
Family: Transporter
Novelty: 0.05441047
p_int: 0.85259045
p_ni: 0.14740955
Data Source: BioPlex
Publication Statistics
PubMed Score  77.86

PubMed score by year
PubTator Score  46.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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