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Tbio
DERL2
Derlin-2

Protein Classes
Protein Summary
Description
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000158771
  • ENSP00000158771
  • ENSG00000072849

Symbol
  • DER2
  • FLANA
  • FLANa
  • F-LANa
  • CGI-101
  • F-LAN-1
  • derlin-2
  • DERtrin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.94
histone modification site profile
0.9
transcription factor binding site profile
0.75
cell type or tissue
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
3
9
85.2
myeloid white cell count
1
1
1
78.1
mean platelet volume
1
1
1
74.2
leukocyte count
1
1
1
73.9
neutrophil count
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
85.2
myeloid white cell count
1
78.1
mean platelet volume
1
74.2
leukocyte count
1
73.9
neutrophil count
2
64.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
derlin 2
VGNC:12090
455251
Macaque
derlin 2
712051
Mouse
MGI:2151483
116891
Dog
derlin 2
VGNC:39903
606991
Horse
derlin 2
VGNC:17137
100061027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
derlin 2
Macaque
derlin 2
Mouse
Dog
derlin 2
Horse
derlin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZP9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (135)
1 – 10 of 135
NAT8B
Tbio
Family:  Enzyme
p_int:  0.891893678
p_ni:  0.108105815
p_wrong:  5.07e-7
Data Source:  BioPlex
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.879395458
p_ni:  0.120600058
p_wrong:  0.000004485
Score:  0.261
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.869812219
p_ni:  0.130179855
p_wrong:  0.000007926
Score:  0.987
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.841206775
p_ni:  0.158793171
p_wrong:  5.4e-8
Data Source:  BioPlex
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.999
Data Source:  Reactome,STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.998
Data Source:  Reactome,STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.997
Data Source:  Reactome,STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
Score:  0.997
Data Source:  STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.996
Data Source:  Reactome,STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.995
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  37.89

PubMed score by year
PubTator Score  14.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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