Tbio NRSN2 Neurensin-2

Protein Summary

Description

May play a role in maintenance and/or transport of vesicles.

Uniprot Accession IDs

• Q9GZP1
• A8K3B2
• Q6FII5
• Q9NUD3

Gene Name

• NRSN2

Ensembl ID

• ENST00000382285
• ENSP00000371722
• ENSG00000125841
• ENST00000382291
• ENSP00000371728
• ENST00000621012
• ENSP00000482706

Symbol

• C20orf98
• C20orf98
• dJ1103G7.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.62
small molecule perturbation	0.59
cell type or tissue	0.54
histone modification site profile	0.53
cellular component	0.52

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (7)

Components (6)

Processes (1)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
plasma membrane	Inferred from Direct Assay (IDA)	LIFEdb
cytoplasmic vesicle	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuron projection	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuronal cell body	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transport vesicle	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

CD1B

Tbio

Novelty: 0.00152228

p_int: 0.999773873

p_ni: 0.000183493

p_wrong: 0.000042634

Score: 0.179

Data Source: BioPlex,STRINGDB

FAM234B

Tdark

Novelty: 9.9

p_int: 0.999643654

p_ni: 0.000165682

p_wrong: 0.000190664

Score: 0.186

Data Source: BioPlex,STRINGDB

FITM2

Tdark

Novelty: 0.02272483

p_int: 0.854995215

p_ni: 0.125395719

p_wrong: 0.019609066

Score: 0.161

Data Source: BioPlex,STRINGDB

MANSC1

Tdark

Novelty: 1.42372881

p_int: 0.805439615

p_ni: 0.002520866

p_wrong: 0.192039519

Data Source: BioPlex

ZDHHC17

Tbio

Family: Enzyme

Novelty: 0.03352984

p_int: 0.757418258

p_ni: 0.242581718

p_wrong: 2.4e-8

Score: 0.214

Data Source: BioPlex,STRINGDB

ZBBX

Tdark

Novelty: 5.95833333

Score: 0.732

Data Source: STRINGDB

WDR49

Tdark

Score: 0.667

Data Source: STRINGDB

ARMCX2

Tdark

Novelty: 0.26022305

Score: 0.651

Data Source: STRINGDB

NECAP2

Tdark

Novelty: 0.58353317

Score: 0.636

Data Source: STRINGDB

FSTL5

Tbio

Novelty: 0.14507772

Score: 0.627

Data Source: STRINGDB

Publication Statistics

PubMed Score  4.78

PubMed score by year

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PubTator Score  3.25

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDDPEGPPVLCPRRPWPSLCWKISLSSGT

1-70

LLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYNQALGTCRLAGTALCVAAGVLLAICLFWAMIG

70-140

WLSQDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQSWFSPPASPFGQSSVQTIQPKRDS

140-204

MMPSCNRSCSCSRGPSVEDGKWYGVRSYLHLFYEDCAGTALSDDPEGPPVLCPRRPWPSLCWKISLSSGTLLLLLGVAALTTGYAVPPKLEGIGEGEFLVLDQRAADYNQALGTCRLAGTALCVAAGVLLAICLFWAMIGWLSQDTKAEPLDPEADSHVEVFGDEPEQQLSPIFRNASGQSWFSPPASPFGQSSVQTIQPKRDS

Find similar targets by:

Uniprot Keyword

Complete proteome
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix