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Tbio
PDGFD
Platelet-derived growth factor D

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-ter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302251
  • ENSP00000302193
  • ENSG00000170962
  • ENST00000393158
  • ENSP00000376865

Symbol
  • IEGF
  • SCDGFB
  • IEGF
  • SCDGFB
  • MSTP036
  • SCDGF-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.64
phenotype
0.61
tissue sample
0.6
biological term
0.59
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.96   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.96   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
60.1
visual cortical surface area measurement
1
1
1
40.7
adrenal suppression measurement
2
1
0
5
39.6
response to corticosteroid
2
1
0
5
39.6
apolipoprotein A 1 measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
60.1
visual cortical surface area measurement
1
40.7
adrenal suppression measurement
0
5
39.6
response to corticosteroid
0
5
39.6
apolipoprotein A 1 measurement
1
30.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor D
VGNC:1092
466765
Macaque
platelet derived growth factor D
704310
Mouse
MGI:1919035
71785
Rat
RGD:621880
66018
Dog
platelet derived growth factor D
VGNC:44371
479460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor D
Macaque
platelet derived growth factor D
Mouse
Rat
Dog
platelet derived growth factor D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (80)
1 – 10 of 80
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999898357
p_ni:  0.000101626
p_wrong:  1.7e-8
Data Source:  BioPlex
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.999833151
p_ni:  0.000165805
p_wrong:  0.000001044
Score:  0.696
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999602909
p_ni:  0.000397089
p_wrong:  2e-9
Score:  0.696
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.9932284
p_ni:  0.0067716
Data Source:  BioPlex
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.989898729
p_ni:  0.010101271
Score:  0.75
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.978806447
p_ni:  0.021193524
p_wrong:  2.9e-8
Score:  0.581
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.971500113
p_ni:  0.028499887
Data Source:  BioPlex
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.966085055
p_ni:  0.033914945
Score:  0.775
Data Source:  BioPlex,STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
p_int:  0.964025233
p_ni:  0.035974767
Score:  0.175
Data Source:  BioPlex,STRINGDB
UBR5
Tbio
Family:  Enzyme
Novelty:  0.00608732
p_int:  0.94359213
p_ni:  0.05640787
Data Source:  BioPlex
Publication Statistics
PubMed Score  147.96

PubMed score by year
PubTator Score  66.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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