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Tbio
TGIF2
Homeobox protein TGIF2

Protein Summary
Description
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373872
  • ENSP00000362979
  • ENSG00000118707
  • ENST00000373874
  • ENSP00000362981
  • ENST00000560025
  • ENSP00000453773
  • ENST00000611732
  • ENSP00000481787
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.92
transcription factor binding site profile
0.87
microRNA
0.74
tissue sample
0.65
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.25   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.25   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
86.9
1
1
0
1.3
60.5
appendicular lean mass
1
1
1
50.6
1
1
0
1.3
38.8
gut microbiome measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
86.9
0
1.3
60.5
appendicular lean mass
1
50.6
0
1.3
38.8
gut microbiome measurement
1
17.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TGFB induced factor homeobox 2
VGNC:10009
101057323
Rat
RGD:1560115
499929
Dog
TGFB induced factor homeobox 2
VGNC:47314
485857
Horse
TGFB induced factor homeobox 2
VGNC:24059
102149210
Cow
TGFB induced factor homeobox 2
VGNC:35808
535632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TGFB induced factor homeobox 2
Rat
Dog
TGFB induced factor homeobox 2
Horse
TGFB induced factor homeobox 2
Cow
TGFB induced factor homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZN2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (45)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Protein-Protein Interactions (19)
1 – 10 of 19
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.942
Data Source:  Reactome,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.938
Data Source:  Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.932
Data Source:  Reactome,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.929
Data Source:  Reactome,STRINGDB
SERPINE1
Tchem
Novelty:  0.00017629
Score:  0.902
Data Source:  STRINGDB
PABPC5
Tdark
Novelty:  0.36077159
Score:  0.839
Data Source:  STRINGDB
TGIF1
Tbio
Family:  TF
Novelty:  0.02218661
Score:  0.817
Data Source:  STRINGDB
TGFBI
Tbio
Novelty:  0.00154768
Score:  0.805
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.556
Data Source:  STRINGDB
PCDH11X
Tbio
Novelty:  0.00588287
Score:  0.536
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.25

PubMed score by year
PubTator Score  16.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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